N
Niels Grabe
Researcher at Heidelberg University
Publications - 128
Citations - 5720
Niels Grabe is an academic researcher from Heidelberg University. The author has contributed to research in topics: Head and neck squamous-cell carcinoma & Cancer. The author has an hindex of 34, co-authored 125 publications receiving 4563 citations. Previous affiliations of Niels Grabe include University Hospital Heidelberg & Otto-von-Guericke University Magdeburg.
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Journal ArticleDOI
F-18 labelled PSMA-1007: biodistribution, radiation dosimetry and histopathological validation of tumor lesions in prostate cancer patients.
Frederik L. Giesel,Boris Hadaschik,Jens Cardinale,Jan Philipp Radtke,Maria Vinsensia,Wencke Lehnert,Claudia Kesch,Y. Tolstov,S. Singer,Niels Grabe,S. Duensing,Martin Schäfer,Oliver C. Neels,Walter Mier,Uwe Haberkorn,Klaus Kopka,Clemens Kratochwil +16 more
TL;DR: The properties of 18F-PSMA-1007 are described, which show its longer half-life combined with its superior energy characteristics and non-urinary excretion overcomes some practical limitations of 68Ga-labelled PSMA-targeted tracers.
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Localization and Density of Immune Cells in the Invasive Margin of Human Colorectal Cancer Liver Metastases Are Prognostic for Response to Chemotherapy
Niels Halama,Sara Michel,Matthias Kloor,Inka Zoernig,Axel Benner,Anna Spille,Thora Pommerencke,Doeberitz Magnus von Knebel,Gunnar Folprecht,Birgit Luber,Nadine Feyen,Uwe M. Martens,Philipp Beckhove,Sacha Gnjatic,Peter Schirmacher,Esther Herpel,Juergen Weitz,Niels Grabe,Dirk Jaeger +18 more
TL;DR: Analysis of tumor-infiltrating lymphocytes (TIL) in primary human colorectal cancer by in situ immunohistochemical staining supports the hypothesis that the adaptive immune response influences the course of human CRC and extends the impact of the local immune response on the clinical course from the primary tumor also to metastatic lesions.
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Tumoral Immune Cell Exploitation in Colorectal Cancer Metastases Can Be Targeted Effectively by Anti-CCR5 Therapy in Cancer Patients.
Niels Halama,Niels Halama,Inka Zoernig,Anna Berthel,Christoph Kahlert,Fee Klupp,Meggy Suarez-Carmona,Thomas Suetterlin,Thomas Suetterlin,Karsten Brand,Juergen Krauss,Felix Lasitschka,Tina Lerchl,Tina Lerchl,Claudia Luckner-Minden,Alexis Ulrich,Moritz Koch,Juergen Weitz,Martin Schneider,Markus W. Buechler,Laurence Zitvogel,Thomas R. W. Herrmann,Axel Benner,Christina Kunz,Stephan Luecke,Christoph Springfeld,Niels Grabe,Niels Grabe,Christine S. Falk,Dirk Jaeger,Dirk Jaeger +30 more
TL;DR: Analyzing the invasive margin of human CRC liver metastases, a mechanism of immune cell exploitation by tumor cells was identified and Mitigation of tumor-promoting inflammation within the tumor tissue and objective tumor responses in CRC were observed.
Journal Article
AliBaba2: context specific identification of transcription factor binding sites.
TL;DR: A method to overcome problems of prediction of transcription factor binding sites by regard identification of binding sites as a general process, starting at a dataset of known binding sites and ending with the identification of a potential new binding site.
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A molecular mechanotransduction pathway regulates collective migration of epithelial cells
TL;DR: It is shown that a tumour suppressor protein, merlin, coordinates collective migration of tens of cells, by acting as a mechanochemical transducer in a stationary epithelial monolayer and in three-dimensional human skin.