L
Lennart Rodén
Researcher at University of Alabama at Birmingham
Publications - 67
Citations - 2846
Lennart Rodén is an academic researcher from University of Alabama at Birmingham. The author has contributed to research in topics: Chondroitin sulfate & Xylosyltransferase. The author has an hindex of 25, co-authored 67 publications receiving 2811 citations. Previous affiliations of Lennart Rodén include Lund University.
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Book ChapterDOI
Structure and Metabolism of Connective Tissue Proteoglycans
TL;DR: The segregation of the proteoglycans into a separate category is based on a few specific characteristics, including the fact that the d-glucuronic-acid-containing repeating disaccharide of chondroitin, N-acetylchondrosine, has recently been identified as a component of thyroglobulin.
Book ChapterDOI
[7] Isolation and characterization of connective tissue polysaccharides
Journal ArticleDOI
Biosynthesis of heparin
TL;DR: In this article, polysaccharide chains composed of a simple, repeating disaccharide unit are modified after synthesis in less than 30 seconds, into a heterogeneous mixture of variously sulfated, complex carbohydrate sequences.
Book ChapterDOI
Biosynthesis of heparin
TL;DR: In this paper, the formation of labeled heparin-precursor polysaccharide from the nucleotide sugars, UDP-[14C]glucuronic acid and UDP-N-acetylglucosamine, in a mouse mastocytoma microsomal fraction was abolished by the addition of 1% Triton X-100.
Journal ArticleDOI
Inhibition of chondroitin and heparan sulfate biosynthesis in Chinese hamster ovary cell mutants defective in galactosyltransferase I.
Jeffrey D. Esko,Julie L. Weinke,William H. Taylor,Göran Ekborg,Lennart Rodén,Gattadahalli M. Anantharamaiah,A. Gawish +6 more
TL;DR: Anion-exchange high performance liquid chromatography of 35S-glycosaminoglycans from one of the galactosyltransferase I-deficient mutants showed a dramatic reduction in both heparan sulfate and chondroitin sulfate, demonstrating that galactOSyl transferase I is responsible for the formation of both glycosaminglycans in intact cells.