L
Leo Tjäderhane
Researcher at Oulu University Hospital
Publications - 231
Citations - 14892
Leo Tjäderhane is an academic researcher from Oulu University Hospital. The author has contributed to research in topics: Dentin & Pulp (tooth). The author has an hindex of 54, co-authored 224 publications receiving 12645 citations. Previous affiliations of Leo Tjäderhane include University of Turku & University of British Columbia.
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State of the art etch-and-rinse adhesives
David H. Pashley,Franklin Chi Meng Tay,Lorenzo Breschi,Leo Tjäderhane,Ricardo M. Carvalho,Marcela Carrilho,Marcela Carrilho,Arzu Tezvergil-Mutluay +7 more
TL;DR: The therapeutic potential of etch-and-rinse adhesives has yet to be fully exploited, and incorporation of protease inhibitors in etchants and/or cross-linking agents in primers may increase the durability of resin-dentin bonds.
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Matrix metalloproteinases (MMPs) in oral diseases.
TL;DR: The history, the current status and the future aspects of the work mainly of the research groups looking at the presence and activity of various MMPs in different oral diseases are described, as well as some of the MMP-related aspects that may facilitate the development of new means of diagnosis and treatment of oral diseases.
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The Activation and Function of Host Matrix Metalloproteinases in Dentin Matrix Breakdown in Caries Lesions
TL;DR: Results demonstrate the pH-dependent activation mechanism of MMPs, which may have a distinct role in different physiological and pathological conditions and demonstrate that host M MPs, activated by bacterial acids, have a crucial role in the destruction of dentin by caries.
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Limitations in Bonding to Dentin and Experimental Strategies to Prevent Bond Degradation
Yan Liu,Leo Tjäderhane,Lorenzo Breschi,Annalisa Mazzoni,Nan Li,Jing Mao,David H. Pashley,Franklin Chi Meng Tay +7 more
TL;DR: Five experimental strategies developed by different research groups for extending the longevity of resin-dentin bonds are examined, finding a combination of several of these strategies should result in overcoming the critical barriers to progress currently encountered in dentin bonding.
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In vivo Preservation of the Hybrid Layer by Chlorhexidine
Marcela Carrilho,Saulo Geraldeli,Franklin R. Tay,M.F. De Goes,Ricardo M. Carvalho,Leo Tjäderhane,André Figueiredo Reis,Josimeri Hebling,Annalisa Mazzoni,Lorenzo Breschi,David H. Pashley +10 more
TL;DR: This study tested the hypothesis that interfacial degradation of resin-dentin bonds may be prevented or delayed by the application of chlorhexidine (CHX), a matrix metalloproteinase inhibitor, to dentin after phosphoric acid-etching.