L
Léon Sanche
Researcher at Université de Sherbrooke
Publications - 441
Citations - 18337
Léon Sanche is an academic researcher from Université de Sherbrooke. The author has contributed to research in topics: Electron & Ion. The author has an hindex of 64, co-authored 432 publications receiving 17111 citations. Previous affiliations of Léon Sanche include Fuzhou University & Open University.
Papers
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Resonant Formation of DNA Strand Breaks by Low-Energy (3 to 20 eV) Electrons
TL;DR: It is shown that reactions of such electrons, even at energies well below ionization thresholds, induce substantial yields of single- and double-strand breaks in DNA, which are caused by rapid decays of transient molecular resonances localized on the DNA's basic components.
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Low energy electron-driven damage in biomolecules
TL;DR: By comparing the results from different experiments and theory, it is possible to determine fundamental mechanisms that are involved in the dissociation of the biomolecules and the production of single- and double-strand breaks in DNA.
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DNA strand breaks induced by 0-4 eV electrons: the role of shape resonances.
TL;DR: Collisions of 0-4 eV electrons with thin DNA films are shown to produce single strand breaks, which support aspects of a theoretical study by Barrios et al. indicating that such a mechanism could produce strand breaks in DNA.
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Single, double, and multiple double strand breaks induced in DNA by 3-100 eV electrons.
TL;DR: It is shown that below 15 eV such low-energy electrons induce single (SSB) and double (DSB) strand breaks in plasmid DNA exclusively via formation and decay of molecular resonances involving DNA components (base, sugar, hydration water, etc.).
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Biomolecular Damage Induced by Ionizing Radiation: The Direct and Indirect Effects of Low-Energy Electrons on DNA
TL;DR: The current understanding of the fundamental mechanisms involved in LEE-induced damage of DNA and complex biomolecule films is summarized and the potential of controlling this damage using molecular and nanoparticle targets with high LEE yields in targeted radiation-based cancer therapies is discussed.