L
Leonard D. Shultz
Researcher at Tottori University
Publications - 3
Citations - 2050
Leonard D. Shultz is an academic researcher from Tottori University. The author has contributed to research in topics: Transgene & Haematopoiesis. The author has an hindex of 2, co-authored 3 publications receiving 1989 citations.
Papers
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Journal ArticleDOI
The murine mutation osteopetrosis is in the coding region of the macrophage colony stimulating factor gene
Hisahiro Yoshida,Shin-Ichi Hayashi,Takahiro Kunisada,Minetaro Ogawa,Satomi Nishikawa,Hitoshi Okamura,Tetsuo Sudo,Leonard D. Shultz,Shin Ichi Nishikawa +8 more
TL;DR: It is shown that op/op fibroblasts are defective in production of functional macrophage colony-stimulating factor (M-CSF), although its messenger RNA (Csfm mRNA) is present at normal levels, and it is concluded that the pathological changes in this mutant result from the absence of M- CSF.
Journal ArticleDOI
Transgene expression of steel factor in the basal layer of epidermis promotes survival, proliferation, differentiation and migration of melanocyte precursors
Takahiro Kunisada,Hisahiro Yoshida,Hidetoshi Yamazaki,Akitomo Miyamoto,Hiroaki Hemmi,Emi K. Nishimura,Leonard D. Shultz,Shin-Ichi Nishikawa,Shin-Ichi Hayashi +8 more
TL;DR: Data is presented suggesting that SLF does not simply support survival and proliferation of melanocytes but also promotes differentiation of these cells, and unexpected melanocyte stem cells independent of the c-Kit signal were maintained in the skin of the SLF transgenic mice.
Patent
Psoriasis vulgaris model mouse and method for producing same
TL;DR: In this paper, the authors presented a method for producing an immunologically humanized mouse, the method comprising: transferring human hematopoietic stem cells into an NOD/SCID mouse that carries a human IL-6 locus on the chromosome thereof and that lacks the function of the IL-2 receptor gamma chain; and breeding said mouse.