T
Takahiro Kunisada
Researcher at Gifu University
Publications - 188
Citations - 12211
Takahiro Kunisada is an academic researcher from Gifu University. The author has contributed to research in topics: Stem cell & Embryonic stem cell. The author has an hindex of 48, co-authored 185 publications receiving 11413 citations. Previous affiliations of Takahiro Kunisada include Kyoto University & St. Marianna University School of Medicine.
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Journal ArticleDOI
The murine mutation osteopetrosis is in the coding region of the macrophage colony stimulating factor gene
Hisahiro Yoshida,Shin-Ichi Hayashi,Takahiro Kunisada,Minetaro Ogawa,Satomi Nishikawa,Hitoshi Okamura,Tetsuo Sudo,Leonard D. Shultz,Shin Ichi Nishikawa +8 more
TL;DR: It is shown that op/op fibroblasts are defective in production of functional macrophage colony-stimulating factor (M-CSF), although its messenger RNA (Csfm mRNA) is present at normal levels, and it is concluded that the pathological changes in this mutant result from the absence of M- CSF.
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A more efficient method to generate integration-free human iPS cells
Keisuke Okita,Yasuko Matsumura,Yoshiko Sato,Aki Okada,Asuka Morizane,Satoshi Okamoto,Hyenjong Hong,Masato Nakagawa,Koji Tanabe,Ken-ichi Tezuka,Toshiyuki Shibata,Takahiro Kunisada,Masayo Takahashi,Jun Takahashi,Hiroh Saji,Shinya Yamanaka +15 more
TL;DR: A simple method is reported, using p53 suppression and nontransforming L-Myc, to generate human induced pluripotent stem cells (iPSCs) with episomal plasmid vectors, which may provide iPSCs suitable for autologous and allologous stem-cell therapy in the future.
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Hypoxia promotes expansion of the CD133-positive glioma stem cells through activation of HIF-1alpha.
A Soeda,M Park,Dae Hee Lee,Arlan Mintz,Andreas Androutsellis-Theotokis,Ronald D.G. McKay,Johnathan A. Engh,Toru Iwama,Takahiro Kunisada,Amin B. Kassam,Ian F. Pollack,Deric M. Park +11 more
TL;DR: It is shown that hypoxia (1% oxygen) promotes the self-renewal capacity of CD133-positive human glioma-derived cancer stem cells (CSCs) and the activation of HIF-1α to enhance theSelf-Renewal activity of CD 133-positive cells and to inhibit the induction of CSC differentiation.
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Characterization of CD133+ hepatocellular carcinoma cells as cancer stem/progenitor cells ☆
Atsushi Suetsugu,Masahito Nagaki,Hitomi Aoki,Tsutomu Motohashi,Takahiro Kunisada,Hisataka Moriwaki +5 more
TL;DR: Investigation of whether CD133(+) cells isolated from human hepatocellular carcinoma cell lines possess cancer stem/progenitor cell-like properties found that among the three cell lines studied, the CD133 antigen was found to be expressed only on the surface of Huh-7 cells.
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Topical drug rescue strategy and skin protection based on the role of Mc1r in UV-induced tanning
John A. D'Orazio,Tetsuji Nobuhisa,Tetsuji Nobuhisa,Rutao Cui,Rutao Cui,Michelle Arya,Michelle Arya,Malinda Spry,Kazumasa Wakamatsu,Vivien Igras,Vivien Igras,Takahiro Kunisada,Scott R. Granter,Emi K. Nishimura,Shosuke Ito,David E. Fisher,David E. Fisher +16 more
TL;DR: It is shown that ultraviolet light potently induces expression of MSH in keratinocytes, but fails to stimulate pigmentation in the absence of functional MC1R in red/blonde-haired Mc1re/e mice, and a clinical strategy for topical small-molecule manipulation of pigmentation is suggested.