L
Leonardo L. G. Ferreira
Researcher at University of São Paulo
Publications - 64
Citations - 2091
Leonardo L. G. Ferreira is an academic researcher from University of São Paulo. The author has contributed to research in topics: Medicine & Virtual screening. The author has an hindex of 14, co-authored 54 publications receiving 1215 citations.
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Molecular Docking and Structure-Based Drug Design Strategies
TL;DR: The purpose of this review is to examine current molecular docking strategies used in drug discovery and medicinal chemistry, exploring the advances in the field and the role played by the integration of structure- and ligand-based methods.
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ADMET modeling approaches in drug discovery.
TL;DR: In silico prediction of ADMET is an important component of pharmaceutical R&D and has advanced alongside the progress of chemoinformatics, which has evolved from traditional chemometrics to advanced machine learning methods.
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Drug repositioning approaches to parasitic diseases: a medicinal chemistry perspective.
TL;DR: Drug repositioning has played a key part in improving the lives of those suffering from neglected tropical diseases, as evidenced by successful precedents and recent studies on preeminent parasitic disorders.
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Targeting cysteine proteases in trypanosomatid disease drug discovery
TL;DR: Given that current chemotherapy for Chagas disease and human African trypanosomiasis has several drawbacks, cysteine proteases will continue to be actively pursued as valuable molecular targets in trypanOSomatid disease drug discovery efforts.
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Phenotypic screening of nonsteroidal anti-inflammatory drugs identified mefenamic acid as a drug for the treatment of schistosomiasis.
Eloi M Lago,Marcos P. Silva,Talita Gonçalves Aires de Queiroz,Susana F. Mazloum,Vinícius C. Rodrigues,Paulo U. Carnaúba,Pedro Luiz Silva Pinto,Jefferson Almeida Rocha,Leonardo L. G. Ferreira,Adriano D. Andricopulo,Josué de Moraes +10 more
TL;DR: The capacity of mefenamic acid to act as a potent anti-schistosomal agent suitable for clinical repurposing in the treatment of schistosomiasis is demonstrated.