L
Leslie J. Klaff
Researcher at University of Washington
Publications - 36
Citations - 2044
Leslie J. Klaff is an academic researcher from University of Washington. The author has contributed to research in topics: Insulin & Diabetes mellitus. The author has an hindex of 15, co-authored 31 publications receiving 1339 citations.
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Journal ArticleDOI
The Performance and Usability of a Factory-Calibrated Flash Glucose Monitoring System.
TL;DR: Interstitial glucose measurements with the FreeStyle Libre system were found to be accurate compared with capillary BG reference values, with accuracy remaining stable over 14 days of wear and unaffected by patient characteristics.
Journal ArticleDOI
Tirzepatide once weekly for the treatment of obesity in people with type 2 diabetes (SURMOUNT-2): a double-blind, randomised, multicentre, placebo-controlled, phase 3 trial
W. Timothy Garvey,Ania M. Jastreboff,Carel W. le Roux,Naveed Sattar,Diego Aizenberg,Huzhang Mao,Shuyu Zhang,Nadia N. Ahmad,Mathijs C. Bunck,Imane Benabbad,Xiaotian M. Zhang,Federico C Perez Manghi,Cesar J Zaidman,Marisa Liliana Vico,Pablo R. Costanzo,Leonardo Serra,Ignacio MacKinnon,Miguel N. Hissa,M. Vidotti,José Francisco Kerr Saraiva,Bakke O Alves,Denise Reis Franco,S. Murthy,Ghanshyam Goyal,Yoshimitsu Yamasaki,Nobuyuki Sato,Satoshi Inoue,Taro Asakura,M. Shestakova,E. Khaykina,Ekaterina A. Troshina,Natalia V Vorokhobina,Alexander Ametov,Shih-Te Tu,Chwen-Yi Yang,I. Lee,Chien-Ning Huang,Horng Yih Ou,George Freeman,Sriram Machineni,K Klein,Senan Sultan,Alan A. Parsa,Alexy González,Anuj Bhargava,Susan R. Brian,Carlos Ince,Stephen Plantholt,J. Cole,Dámaris Opazo Vega,José Neuman de Souza,Jane Rohlf,Barry S. Horowitz,Rodolfo J. Galindo,Jamy D. Ard,Brian D. Curtis,Neil J. Fraser,José M. Mandry,Rizwana Mohseni,Ronald K. Mayfield,Charles B. Vance,Stephen Ong,Alexander Murray,Amer Al-Karadsheh,Tamer Yacoub,Kevin Roberts,David Fried,Julio Rosenstock,B. Bode,Juan P. Frias,Leslie J. Klaff,Ronald L. Brazg,Joanna Van,Anjanette Tan,Toby Briskin,M. J. Rhee,Tira Chaicha-Brom,Paul Hartley,L. de Nunez,Gregorio Cortes-Maisonet,G. Soucie,Stanley H. Hsia,Thomas C. Jones +82 more
TL;DR: In this 72-week trial in participants with obesity, 5 mg, 10 mg, or 15 mg of tirzepatide once weekly provided substantial and sustained reductions in body weight.
Journal ArticleDOI
A Prospective Multicenter Evaluation of the Accuracy of a Novel Implanted Continuous Glucose Sensor: PRECISE II.
Mark P. Christiansen,Leslie J. Klaff,Ronald L. Brazg,Anna R Chang,Carol J. Levy,David K. Lam,Douglas S Denham,George Atiee,Bruce W. Bode,Steven J Walters,Lynne Kelley,Timothy S. Bailey +11 more
TL;DR: The PRECISE II trial demonstrated that the Eversense CGM system provided accurate glucose readings through the intended 90-day sensor life with a favorable safety profile.
Journal ArticleDOI
Intra-islet insulin permits glucose to directly suppress pancreatic A cell function.
TL;DR: It is concluded that intra-islet insulin permits glucose to suppress glucagon secretion and stimulate somatostatin during hyperglycemia.
Journal ArticleDOI
Comparative glycemic control, safety and patient ratings for a new 4 mm x 32G insulin pen needle in adults with diabetes.
Laurence J. Hirsch,Michael Gibney,John Albanese,Shankang Qu,Kenneth Kassler-Taub,Leslie J. Klaff,Timothy S. Bailey +6 more
TL;DR: The 4 mm × 32G PN provided equivalent glycemic control compared to 31G, 5’mm and 8”mm PNs with reduced pain, no difference in insulin leakage and was preferred by patients.