The Performance and Usability of a Factory-Calibrated Flash Glucose Monitoring System.
TLDR
Interstitial glucose measurements with the FreeStyle Libre system were found to be accurate compared with capillary BG reference values, with accuracy remaining stable over 14 days of wear and unaffected by patient characteristics.Abstract:
Introduction: The purpose of the study was to evaluate the performance and usability of the FreeStyle® Libre™ Flash glucose monitoring system (Abbott Diabetes Care, Alameda, CA) for interstitial glucose results compared with capillary blood glucose results. Materials and Methods: Seventy-two study participants with type 1 or type 2 diabetes were enrolled by four U.S. clinical sites. A sensor was inserted on the back of each upper arm for up to 14 days. Three factory-only calibrated sensor lots were used in the study. Sensor glucose measurements were compared with capillary blood glucose (BG) results (approximately eight per day) obtained using the BG meter built into the reader (BG reference) and with the YSI analyzer (Yellow Springs Instrument, Yellow Springs, OH) reference tests at three clinic visits (32 samples per visit). Sensor readings were masked to the participants. Results: The accuracy of the results was demonstrated against capillary BG reference values, with 86.7% of sensor results w...read more
Citations
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Continuous Glucose Monitoring: A Review of Successes, Challenges, and Opportunities
TL;DR: Continuous glucose monitoring in conjunction with an insulin pump with automated suspension of insulin infusion in response to actual observed or predicted hypoglycemia, as well as progressive refinement of closed-loop systems, is expected to dramatically enhance the clinical utility and utilization of CGM.
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Ten-Hour Time-Restricted Eating Reduces Weight, Blood Pressure, and Atherogenic Lipids in Patients with Metabolic Syndrome
Michael J. Wilkinson,Emily N. C. Manoogian,Adena Zadourian,Hannah Lo,Savannah Fakhouri,Azarin Shoghi,Xinran Wang,Jason G. Fleischer,Saket Navlakha,Satchidananda Panda,Pam R. Taub +10 more
TL;DR: This TRE intervention improves cardiometabolic health for patients with metabolic syndrome receiving standard medical care including high rates of statin and anti-hypertensive use and is a potentially powerful lifestyle intervention that can be added to standard medical practice to treat metabolic syndrome.
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ISPAD Clinical Practice Consensus Guidelines 2018: Glycemic control targets and glucose monitoring for children, adolescents, and young adults with diabetes
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Electrochemical glucose sensors in diabetes management: an updated review (2010-2020).
TL;DR: The scope of this review is to present the key scientific and technological advances in electrochemical glucose biosensing over the past decade, along with current obstacles and prospects towards the ultimate goal of highly stable and reliable real-time minimally- invasive or non-invasive glucose monitoring.
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Accessing analytes in biofluids for peripheral biochemical monitoring
Jason Heikenfeld,Andrew J. Jajack,Benjamin Feldman,Steve W. Granger,Supriya Gaitonde,Gavi Begtrup,Benjamin Katchman +6 more
TL;DR: The range of biochemical analytes that can be sensed in dermal interstitial fluid, saliva and sweat are surveyed, and criteria for tailoring sensor design to address the right analyte in the right body site for the right disease or wellness application are outlined.
References
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Effectiveness of Sensor-Augmented Insulin-Pump Therapy in Type 1 Diabetes
Richard M. Bergenstal,William V. Tamborlane,Andrew J. Ahmann,John B. Buse,George Dailey,Stephen N. Davis,Carol Joyce,Tim Peoples,Bruce A. Perkins,John B. Welsh,Steven M. Willi,Michael A. Wood +11 more
TL;DR: In both adults and children with inadequately controlled type 1 diabetes, sensor-augmented pump therapy resulted in significant improvement in glycated hemoglobin levels, as compared with injection therapy.
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Effect of Continuous Glucose Monitoring on Hypoglycemia in Type 1 Diabetes
TL;DR: Continuous glucose monitoring was associated with reduced time spent in hypoglycemia and a concomitant decrease in HbA1c in children and adults with type 1 diabetes.
Journal ArticleDOI
The effect of continuous glucose monitoring in well-controlled type 1 diabetes.
Roy W. Beck,Irl B. Hirsch,Lori M.B. Laffel,William V. Tamborlane,Bruce W. Bode,Bruce A. Buckingham,Peter Chase,Robert Clemons,Rosanna Fiallo-Scharer,Larry A. Fox,Lisa K. Gilliam,Elbert S. Huang,Craig Kollman,Aaron J. Kowalski,Jean M. Lawrence,Joyce M. Lee,Nelly Mauras,Michael J. O'Grady,Katrina J. Ruedy,Michael Tansey,Eva Tsalikian,Stuart A. Weinzimer,Darrell M. Wilson,Howard Wolpert,Tim Wysocki,Dongyuan Xing +25 more
TL;DR: The weight of evidence suggests that CGM is beneficial for individuals with type 1 diabetes who have already achieved excellent control with A1C <7.0% and most outcomes, including those combining A 1C and hypoglycemia, favored the CGM group.
Journal ArticleDOI
Glucose meters: A review of technical challenges to obtaining accurate results
TL;DR: The challenges involved in obtaining accurate glucose meter results are reviewed, including multiple complexities involved in defining technical accuracy and no clear consensus among standards agencies and professional societies on accuracy criteria.
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Sensor-augmented insulin pump therapy: results of the first randomized treat-to-target study.
Irl B. Hirsch,Jill M. Abelseth,Bruce W. Bode,Jerome S Fischer,Francine R. Kaufman,John J. Mastrototaro,Christopher G. Parkin,Howard Wolpert,Bruce A. Buckingham +8 more
TL;DR: Subjects in the CG group had increased hypoglycemia AUC and number of events during blinded CGM use; however, there was no increase in hypoglycephalic area under the curve (AUC) or number of Events in the SG group.
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