Peter J. Havel

TL;DR: The data suggest that dietary fructose specifically increases DNL, promotes dyslipidemia, decreases insulin sensitivity, and increases visceral adiposity in overweight/obese adults.

TL;DR: It is suggested that adiponectin concentrations are determined by intra-abdominal fat mass, with additional independent effects of age and sex, and could link intra- abdominalFat with insulin resistance and an atherogenic lipoprotein profile.

TL;DR: Although there are existing data on the metabolic and endocrine effects of dietary fructose that suggest that increased consumption of fructose may be detrimental in terms of body weight and adiposity and the metabolic indexes associated with the insulin resistance syndrome, much more research is needed to fully understand the metabolic effect of dietaryructose in humans.

TL;DR: Reductions of circulating insulin and leptin and increased ghrelin concentrations, as demonstrated in this study, could lead to increased caloric intake and ultimately contribute to weight gain and obesity during chronic consumption of diets high in fructose.

TL;DR: A review of the biology, actions, and regulation of three adipocyte hormones-leptin, acylation stimulating protein (ASP), and adiponectin-with an emphasis on the most recent literature is presented in this article.