Leslie O. Schulz

TL;DR: It is shown that obesity is less prevalent among people of Pima heritage living a “traditional” lifestyle than among Pimas living in an “affluent” environment, and that a traditional lifestyle, characterized by a diet including less animal fat and more complex carbohydrates and by greater energy expenditure in physical labor, may protect against the development of cardiovascular disease risk factors, obesity, and NIDDM.

TL;DR: The much lower prevalence of type 2 diabetes and obesity in the Pima Indians in Mexico than in the U.S. indicates that even in populations genetically prone to these conditions, their development is determined mostly by environmental circumstances, thereby suggesting that type 1 diabetes is largely preventable.

TL;DR: An initial study of the nature of linkage disequilibrium and genetic variation, in population samples from different regions of the world, in a larger segment of the ADH cluster (including the three Class I ADH genes and ADH7), indicates that most ADH-alcoholism association studies have failed to consider many sites in theADH cluster that may harbor etiologically significant alleles and that the relevance of the various ADH sites will be population dependent.

TL;DR: A significant role for physical activity in the prevention of obesity in genetically susceptible populations is supported by measuring total energy expenditure in Mexican and USA Pima Indians.

TL;DR: It is demonstrated that total daily energy expenditure varies dramatically among healthy, free-living adults, and the relationship between body fatness and nonbasal energy expenditure was negative at high energy outputs but considerable variation in bodyfatness was present among sedentary individuals, suggesting that a low rate of nonbasAL energy expenditure is a permissive factor for obesity.