L
Leslie P. Weiner
Researcher at University of Southern California
Publications - 111
Citations - 7972
Leslie P. Weiner is an academic researcher from University of Southern California. The author has contributed to research in topics: Virus & Multiple sclerosis. The author has an hindex of 47, co-authored 111 publications receiving 7766 citations. Previous affiliations of Leslie P. Weiner include Johns Hopkins University School of Medicine & City of Hope National Medical Center.
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Transgenic mice that express a myelin basic protein-specific T cell receptor develop spontaneous autoimmunity
TL;DR: A transgenic mouse model that mimics the human autoimmune disease multiple sclerosis in its spontaneous induction and pathology is constructed and a unique opportunity to dissect the genetic and environmental variables that may contribute to the development of spontaneous autoimmune disease is afforded.
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Extended use of glatiramer acetate (Copaxone) is well tolerated and maintains its clinical effect on multiple sclerosis relapse rate and degree of disability
Kenneth P. Johnson,Benjamin Rix Brooks,Jeffrey A. Cohen,Corey C. Ford,Jonathan Goldstein,R. P. Lisak,Lawrence W. Myers,Hillel Panitch,J. W. Rose,R. B. Schiffer,Timothy Vollmer,Leslie P. Weiner,Jerry S. Wolinsky +12 more
TL;DR: The clinical benefit of glatiramer acetate for both the relapse rate and for neurologic disability was sustained at the end of the extension trial.
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Pathogenesis of demyelination induced by a mouse hepatitis.
TL;DR: Demyelinative lesions produced in mice by inoculation of JHM virus, a neurotropic strain of mouse hepatitis virus, appeared to be the direct result of infection of glial cells of the white matter.
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Pathogenicity of antigenic variants of murine coronavirus JHM selected with monoclonal antibodies.
TL;DR: To analyze the pathogenesis of the neurotropic murine coronavirus JHMV, monoclonal antibodies to the E2 viral glycoprotein were used to select antigenic variant viruses and demyelinating variants with reduced neurovirulence were selected.
Journal Article
Effect of estradiol on cytokine secretion by proteolipid protein-specific T cell clones isolated from multiple sclerosis patients and normal control subjects.
TL;DR: The ability of estradiol (E2) to modulate the secretion of cytokines by CD4+ T cells was investigated using neuroantigen-specific T cell clones isolated from normal control subjects and patients with the demyelinating disease, multiple sclerosis, to indicate that E2 is capable of modulating both pro- and anti-inflammatory activities of CD4- T cells.