Leslie Y. M. Chin

TL;DR: The successful establishment of a postcrisis SV40 large T-antigen transformed epithelial cell line derived from human bronchial epithelium is described, and this cell line, 16HBE14o- cells, provides a valuable resource for studying the modulation of CFTR and its role in regulation of chloride ion transport in human airway epithelia as well as other aspects of human airways cell biology.

TL;DR: The mechanical properties of human ASM from asthmatic and nonasthmatic subjects are comparable except for increased passive stiffness and attenuated decline in force generation after an oscillatory perturbation, which may relate to reduced bronchodilation induced by a deep inspiration inAsthmatic subjects.

TL;DR: These cells demonstrate that it is possible to select transformed cell clones with particular morphologic characteristics, i.e. the presence of tight junctions and cell polarity, which also retain useful epithelial cell-specific functions, including vectorial ion transport.

TL;DR: Cl- transport measured by 36Cl efflux shows that CF gland epithelial cells, like CF surface airway and nasal polyp epithel cells, are unable to respond to increases in intracellular cAMP, however, they do produce an increase in intrusion cAMP after treatment with isoproterenol or forskolin.

TL;DR: A rare familial leukodystrophy is described in three sisters characterized clinically by palatal myoclonus, spastic weakness, hyperreflexia, mild cerebellar dysfunction, and ocular motor abnormalities.