Lester Weiss

TL;DR: The frequencies of balanced chromosome rearrangements were estimated from three series of advanced maternal-age prenatal genetic studies, and were compared to the frequencies that had been estimated from consecutive newborn surveys, finding higher estimates may more reliably approximate the true mutation rate and frequencies in the newborn population.

TL;DR: In general, low numbers of aneuploid cells are not clinically important when observed in blood chromosome preparations of subjects studied because of multiple miscarriages or a family history of autosomal trisomy.

TL;DR: It is proposed that these findings favor a secondary role of the fibroblastic proliferation in myelofibrosis and suggest that the primary cellular disturbance resides only in the hematopoietic cell lines.

TL;DR: Based on observations, three clinical recommendations can be made: obtain a family history of all patients with papillary carcinoma of the thyroid, since between 3.5 to 6.2% will have another affected relative; when two or more persons in a family have papillary cancers, all first- and second-degree relatives should have a neck palpation by an experienced examiner; and families with two orMore persons with papilla carcinoma should be observed for possible colon cancer.

TL;DR: FISH using alpha-satellite sequences, rDNA, and a pTRI-6 satellite I sequence specific to the short arm of chromosome 13 showed all four rearrangements to be dicentric and apparently devoid of ribosomal genes.