L
Letícia V. Costa-Lotufo
Researcher at University of São Paulo
Publications - 313
Citations - 8155
Letícia V. Costa-Lotufo is an academic researcher from University of São Paulo. The author has contributed to research in topics: Cytotoxicity & Cytotoxic T cell. The author has an hindex of 45, co-authored 296 publications receiving 6886 citations. Previous affiliations of Letícia V. Costa-Lotufo include University of California, San Diego & Sao Paulo State University.
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Studies of the anticancer potential of plants used in Bangladeshi folk medicine.
Letícia V. Costa-Lotufo,Mahmud Tareq Hassan Khan,Arjumand Ather,Diego Veras Wilke,Paula C. Jimenez,Cláudia Pessoa,Maria Elisabete Amaral de Moraes,Manoel Odorico de Moraes +7 more
TL;DR: In conclusion, among all tested extracts, only the extracts of Oroxylum indicum, Moringa oleifera and Aegles marmelos could be considered as potential sources of anticancer compounds.
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Overview of the therapeutic potential of piplartine (piperlongumine).
Daniel P. Bezerra,Cláudia Pessoa,Manoel Odorico de Moraes,Nicolau Saker-Neto,E.R. Silveira,Letícia V. Costa-Lotufo +5 more
TL;DR: It is concluded that piplartine is effective for use in cancer therapy and its safety using chronic toxicological studies should be addressed to support the viability of clinical trials.
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In vivo growth-inhibition of Sarcoma 180 by piplartine and piperine, two alkaloid amides from Piper.
Daniel P. Bezerra,Fernanda Oliveira de Castro,Ana Paula Negreiros Nunes Alves,Cláudia Pessoa,Manoel Odorico de Moraes,E.R. Silveira,Mary Anne S. Lima,Francisca Juliana Martins Elmiro,Letícia V. Costa-Lotufo +8 more
TL;DR: Histopathological and morphological analyses of the tumor and the organs, including liver, spleen, and kidney, were performed in order to evaluate the toxicological aspects of the treatment with these amides and it was shown that both organs were reversibly affected by piplartine and piperine treatment, but in a different way.
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Cytotoxic activity of Brazilian Cerrado plants used in traditional medicine against cancer cell lines
Mariana Laundry de Mesquita,José Elias de Paula,Cláudia Pessoa,Manoel Odorico de Moraes,Letícia V. Costa-Lotufo,Raphaël Grougnet,Sylvie Michel,Francois Tillequin,Laila S. Espindola +8 more
TL;DR: To investigate the cytotoxic potential of 412 extracts from Brazilian Cerrado plants used in traditional medicine belonging to 21 families against tumor cell lines in culture,Bioassay-guided fractionation of the last extract led to the isolation of glaucarubinone, which showed pronounced activity against the four cell lines studied.
Journal ArticleDOI
The cytotoxic and embryotoxic effects of kaurenoic acid, a diterpene isolated from Copaifera langsdorffii oleo-resin.
Letícia V. Costa-Lotufo,Geanne M. A. Cunha,P. A. M. Farias,Glauce Socorro de Barros Viana,K.M.A. Cunha,Cláudia Pessoa,Manoel Odorico de Moraes,E.R. Silveira,Nilce V. Gramosa,Vietla Satyanarayana Rao +9 more
TL;DR: The destruction of sea urchin embryos, the inhibition of tumor cell growth and the hemolysis of mouse and human erythrocytes indicate the potential cytotoxicity of kaurenoic acid.