D
Daniel P. Bezerra
Researcher at Oswaldo Cruz Foundation
Publications - 148
Citations - 3840
Daniel P. Bezerra is an academic researcher from Oswaldo Cruz Foundation. The author has contributed to research in topics: Apoptosis & In vivo. The author has an hindex of 31, co-authored 132 publications receiving 3024 citations. Previous affiliations of Daniel P. Bezerra include Universidade Federal de Sergipe & Federal University of Ceará.
Papers
More filters
Journal ArticleDOI
Overview of the therapeutic potential of piplartine (piperlongumine).
Daniel P. Bezerra,Cláudia Pessoa,Manoel Odorico de Moraes,Nicolau Saker-Neto,E.R. Silveira,Letícia V. Costa-Lotufo +5 more
TL;DR: It is concluded that piplartine is effective for use in cancer therapy and its safety using chronic toxicological studies should be addressed to support the viability of clinical trials.
Journal ArticleDOI
In vivo growth-inhibition of Sarcoma 180 by piplartine and piperine, two alkaloid amides from Piper.
Daniel P. Bezerra,Fernanda Oliveira de Castro,Ana Paula Negreiros Nunes Alves,Cláudia Pessoa,Manoel Odorico de Moraes,E.R. Silveira,Mary Anne S. Lima,Francisca Juliana Martins Elmiro,Letícia V. Costa-Lotufo +8 more
TL;DR: Histopathological and morphological analyses of the tumor and the organs, including liver, spleen, and kidney, were performed in order to evaluate the toxicological aspects of the treatment with these amides and it was shown that both organs were reversibly affected by piplartine and piperine treatment, but in a different way.
Journal ArticleDOI
Antitumor properties of a sulfated polysaccharide from the red seaweed Champia feldmannii (Diaz‐Pifferer)
Kézia O.A.L. Lins,Daniel P. Bezerra,Ana Paula Negreiros Nunes Alves,Nylane M.N. Alencar,Michael W. Lima,Valeska Martins Torres,Wladimir Ronald Lobo Farias,Cláudia Pessoa,Manoel Odorico de Moraes,Letícia V. Costa-Lotufo +9 more
TL;DR: Cf‐PLS has some interesting anticancer activity that could be associated with its immunostimulating properties, and acts as an immunomodulatory agent, raising theproduction of specific antibodies, and increasing the production of OVA‐specific antibodies.
Journal ArticleDOI
In vitro and in vivo antitumor effect of 5-FU combined with piplartine and piperine
Daniel P. Bezerra,Fernanda Oliveira de Castro,Ana Paula Negreiros Nunes Alves,Cláudia Pessoa,Manoel Odorico de Moraes,E.R. Silveira,Mary Anne S. Lima,Francisca Juliana Martins Elmiro,Nylane M.N. Alencar,Rodney O. Mesquita,Michael W. Lima,Letícia V. Costa-Lotufo +11 more
TL;DR: Piplartine may enhance the therapeutic effectiveness of chemotherapeutic drugs, and moreover, this combination could improve immunocompetence hampered by 5‐FU, according to the findings.
Journal ArticleDOI
Encapsulation of carvacrol, a monoterpene present in the essential oil of oregano, with β-cyclodextrin, improves the pharmacological response on cancer pain experimental protocols.
Adriana Gibara Guimarães,Marlange A. Oliveira,Rafael dos Santos Alves,Paula dos Passos Menezes,Mairim Russo Serafini,Adriano Antunes de Souza Araújo,Daniel P. Bezerra,Lucindo José Quintans Júnior +7 more
TL;DR: Evidence is produced that the encapsulation of carvacrol in β-cyclodextrin can be useful for the development of new options for pain management, as well as spontaneous and palpation-induced nociception.