L
Li Lin
Researcher at Zhejiang University
Publications - 8
Citations - 3097
Li Lin is an academic researcher from Zhejiang University. The author has contributed to research in topics: Innate immune system & Immune system. The author has an hindex of 8, co-authored 8 publications receiving 2759 citations. Previous affiliations of Li Lin include Laboratory of Molecular Biology & Peking Union Medical College.
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Journal ArticleDOI
The STAT3-binding long noncoding RNA lnc-DC controls human dendritic cell differentiation.
Pin Wang,Yiquan Xue,Yanmei Han,Li Lin,Cong Wu,Sheng Xu,Zhengping Jiang,Junfang Xu,Qiuyan Liu,Xuetao Cao,Xuetao Cao,Xuetao Cao +11 more
TL;DR: A lncRNA expressed exclusively in human dendritic cells (DC), called lnc-DC, is identified that is required for optimal DC differentiation from human monocytes and that regulates DC activation of T cells.
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MicroRNA-146a Feedback Inhibits RIG-I-Dependent Type I IFN Production in Macrophages by Targeting TRAF6, IRAK1, and IRAK2
TL;DR: It is demonstrated that miR-146a, up-regulated during viral infection, is a negative regulator of the RIG-I-dependent antiviral pathway by targeting TRAF6, IRAK1, and IRAK2.
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Identification of miRNomes in Human Liver and Hepatocellular Carcinoma Reveals miR-199a/b-3p as Therapeutic Target for Hepatocellular Carcinoma
Jin Hou,Li Lin,Weiping Zhou,Zhengxin Wang,Guoshan Ding,Qiongzhu Dong,Lun-Xiu Qin,Xiaobing Wu,Yuanyuan Zheng,Yun Yang,Wei Tian,Qian Zhang,Chunmei Wang,Qinghua Zhang,Shi-Mei Zhuang,Limin Zheng,Anmin Liang,Wenzhao Tao,Xuetao Cao,Xuetao Cao +19 more
TL;DR: The third most highly expressed miR-199a/b-3p is consistently decreased in HCC, and its decrement significantly correlates with poor survival of HCC patients and contributes to better understanding of the important deregulated miRNAs in H CC and liver diseases.
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Inducible microRNA-155 Feedback Promotes Type I IFN Signaling in Antiviral Innate Immunity by Targeting Suppressor of Cytokine Signaling 1
Pin Wang,Jin Hou,Li Lin,Chunmei Wang,Xingguang Liu,Dong Li,Feng Ma,Zhugang Wang,Xuetao Cao,Xuetao Cao +9 more
TL;DR: It is demonstrated that inducible miR-155 feedback positively regulates host antiviral innate immune response by promoting type I IFN signaling via targeting SOCS1.
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MicroRNA-99a Inhibits Hepatocellular Carcinoma Growth and Correlates with Prognosis of Patients with Hepatocellular Carcinoma
Dong Li,Xingguang Liu,Li Lin,Jin Hou,Nan Li,Chunmei Wang,Pin Wang,Qian Zhang,Peng Zhang,Weiping Zhou,Zhengxin Wang,Guoshan Ding,Shi-Mei Zhuang,Limin Zheng,Wenzhao Tao,Xuetao Cao,Xuetao Cao +16 more
TL;DR: Conclusively, miR-99a expression was frequently down-regulated in HCC tissues and correlates with the prognosis of HCC patients, thus proposing miR -99a as a prospective prognosis predictor and therapeutic approach for HCC.