L
Li Lu
Researcher at Karolinska Institutet
Publications - 5
Citations - 495
Li Lu is an academic researcher from Karolinska Institutet. The author has contributed to research in topics: Annexin A5 & Affibody molecule. The author has an hindex of 5, co-authored 5 publications receiving 442 citations. Previous affiliations of Li Lu include Karolinska University Hospital.
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Journal ArticleDOI
Vascular endothelial growth factor B controls endothelial fatty acid uptake
Carolina E. Hagberg,Annelie Falkevall,Annelie Falkevall,Xun Wang,Xun Wang,Erik Larsson,Jenni Huusko,Ingrid Nilsson,Laurens A. van Meeteren,Erik Samén,Erik Samén,Li Lu,Maarten Vanwildemeersch,Maarten Vanwildemeersch,Joakim Klar,Joakim Klar,Guillem Genové,Kristian Pietras,Kristian Pietras,Sharon Stone-Elander,Sharon Stone-Elander,Lena Claesson-Welsh,Seppo Ylä-Herttuala,Per Lindahl,Per Lindahl,Ulf Eriksson,Ulf Eriksson +26 more
TL;DR: It is shown that VEGF-B has an unexpected role in endothelial targeting of lipids to peripheral tissues, and may open up the possibility for novel strategies to modulate pathological lipid accumulation in diabetes, obesity and cardiovascular diseases.
Journal ArticleDOI
HER2-Positive Tumors Imaged Within 1 Hour Using a Site-Specifically 11C-Labeled Sel-Tagged Affibody Molecule
Helena Wållberg,Jonas Grafström,Qing Cheng,Li Lu,Li Lu,Hanna-Stina Martinsson Ahlzén,Erik Samén,Erik Samén,Jan-Olov Thorell,Jan-Olov Thorell,Katarina Johansson,Finn Dunås,Maria Hägg Olofsson,Sharon Stone-Elander,Sharon Stone-Elander,Elias S.J. Arnér,Stefan Ståhl +16 more
TL;DR: The finding is that, in a favorable combination between radionuclide half-life and in vivo pharmacokinetics of the Affibody molecules, 11C-labeled Sel-tagged ZHER2:342 can successfully be used for rapid and repeated PET studies of HER2 expression in tumors.
Journal ArticleDOI
Combining [11C]-AnxA5 PET imaging with serum biomarkers for improved detection in live mice of modest cell death in human solid tumor xenografts.
Qing Cheng,Li Lu,Li Lu,Jonas Grafström,Maria Hägg Olofsson,Jan-Olov Thorell,Jan-Olov Thorell,Erik Samén,Erik Samén,Katarina Johansson,Hanna-Stina Martinsson Ahlzén,Sharon Stone-Elander,Sharon Stone-Elander,Stig Linder,Elias S.J. Arnér,Sel-tag imaging +15 more
TL;DR: The combined use of dynamic PET with [11C]-AnxA5-ST, showing specific increases in tumor binding potential upon therapy, with ccK18/K18 serum measurements, as highly sensitive markers for cell death, enabled effective assessment of modest therapy-induced cell death in this mouse xenograft model of solid human tumors.
Journal ArticleDOI
Site-specifically 11C-labeled Sel-tagged annexin A5 and a size-matched control for dynamic in vivo PET imaging of protein distribution in tissues prior to and after induced cell death
Qing Cheng,Li Lu,Li Lu,Jonas Grafström,Maria Hägg Olofsson,Jan-Olov Thorell,Jan-Olov Thorell,Erik Samén,Erik Samén,Katarina Johansson,Hanna-Stina Martinsson Ahlzén,Stig Linder,Elias S.J. Arnér,Sharon Stone-Elander,Sharon Stone-Elander +14 more
TL;DR: Data suggest that the combined use of these two tracers can facilitate differentiating specific AnxA5 binding and its changes caused by induced cell death from uptake due to non-specific permeability and retention effects at baseline or after therapy.
Journal ArticleDOI
Preclinical PET imaging of EGFR levels: pairing a targeting with a non-targeting Sel-tagged Affibody-based tracer to estimate the specific uptake
Qing Cheng,Helena Wållberg,Jonas Grafström,Li Lu,Li Lu,Jan-Olov Thorell,Jan-Olov Thorell,Maria Hägg Olofsson,Stig Linder,Katarina Johansson,Tetyana Tegnebratt,Tetyana Tegnebratt,Elias S.J. Arnér,Sharon Stone-Elander,Sharon Stone-Elander,Hanna-Stina Martinsson Ahlzén,Stefan Ståhl,Sel-tag imaging,Sel-tag imaging,Sel-tag imaging +19 more
TL;DR: Same-day in vivo dual tracer imaging enabled by the Sel-tag technology and 11C-labeling provides a method to non-invasively monitor membrane-localized EGFR as well as factors affecting non-specific uptake of the PET ligand.