L
Li Meng
Researcher at Huazhong University of Science and Technology
Publications - 119
Citations - 2796
Li Meng is an academic researcher from Huazhong University of Science and Technology. The author has contributed to research in topics: Internal medicine & Cancer. The author has an hindex of 28, co-authored 102 publications receiving 2207 citations. Previous affiliations of Li Meng include Tongji Medical College.
Papers
More filters
Journal Article
Overexpression of Vimentin Contributes to Prostate Cancer Invasion and Metastasis via Src Regulation
Juncheng Wei,Gang Xu,Mingfu Wu,Yongtao Zhang,Qiong Li,Ping Liu,Tao Zhu,Anping Song,Liangpin Zhao,Zhiqiang Han,Gang Chen,Shixuan Wang,Li Meng,Jianfeng Zhou,Yunping Lu,Ding Ma +15 more
TL;DR: Vimentin promotes tumor cell invasiveness and the targeting of vimentin/C-src may be a promising strategy for preventing or blocking prostate cancer metastasis.
Journal ArticleDOI
Heterotypic CAF-tumor spheroids promote early peritoneal metastatis of ovarian cancer.
Qinglei Gao,Zongyuan Yang,Sen Xu,Xiaoting Li,Xin Yang,Ping Jin,Yi Liu,Xiaoshui Zhou,Taoran Zhang,Cheng Gong,Xiao Wei,Dan Liu,Chaoyang Sun,Gang Chen,Junbo Hu,Li Meng,Jianfeng Zhou,Kenjiro Sawada,Robert Fruscio,Thomas W. Grunt,Jörg Wischhusen,Víctor Manuel Vargas-Hernández,Bhavana Pothuri,Robert L. Coleman +23 more
TL;DR: These findings identify a specialized MU architecture that amplifies the tumor–stroma interaction and promotes transcoelomic metastasis in HGSOC, providing the basis for stromal fibroblast-oriented interventions in hampering OC peritoneal propagation.
Journal ArticleDOI
RNA interference against HPV16 E7 oncogene leads to viral E6 and E7 suppression in cervical cancer cells and apoptosis via upregulation of Rb and p53
Ni Sima,Ni Sima,Wei Wang,Debo Kong,Dongrui Deng,Qian Xu,Jianfeng Zhou,Gang Xu,Li Meng,Yunping Lu,Shixuan Wang,Ding Ma +11 more
TL;DR: It is demonstrated that 16E7-shRNA can induce simultaneous E6 and E7 suppression and lead to striking apoptosis in HPV16-related cancer cells by activating cellular p53, p21 and Rb and RNAi using E7 shRNA may have the gene-specific therapy potential for HPV 16-related cancers.
Journal ArticleDOI
Activation of fibronectin/PI-3K/Akt2 leads to chemoresistance to docetaxel by regulating survivin protein expression in ovarian and breast cancer cells.
Hui Xing,Danhui Weng,Gang Chen,Wenming Tao,Tao Zhu,Xiaokui Yang,Li Meng,Shixuan Wang,Yunping Lu,Ding Ma +9 more
TL;DR: The results indicate that the activation of Akt2, promoted by FN attachment, might be critical in determining whether cells survive or undergo apoptosis, and targeting the PI-3K/Akt2 pathway might be a promising strategy for enhancing sensitivity to docetaxel in breast or ovarian cancer.
Journal ArticleDOI
Elaiophylin, a novel autophagy inhibitor, exerts antitumor activity as a single agent in ovarian cancer cells.
Xuejiao Zhao,Yong Fang,Yang Yang,Yu Qin,Peng Wu,Ting Wang,Huiling Lai,Li Meng,Dao Wen Wang,Zhihui Zheng,Xin-Hua Lu,Hua Zhang,Qinglei Gao,Jianfeng Zhou,Ding Ma +14 more
TL;DR: It is demonstrated, for the first time, that elaiophylin is a novel autophagy inhibitor, with significant antitumor efficacy as a single agent or in combination in human ovarian cancer cells, establishing the potential treatment of ovarian cancer by this compound.