Li-Ping Liang

TL;DR: Results demonstrate that the ketogenic diet up‐regulates GSH biosynthesis, enhances mitochondrial antioxidant status, and protects mtDNA from oxidant‐induced damage.

TL;DR: Targeting oxidative stress with clinically used drugs for a limited time window starting early after injury significantly improves long-term disease outcomes and may be considered for patients exposed to potential epileptogenic insults.

TL;DR: In mice and rats, MnTE-2-PyP5+ reduced infarct size and improved neurologic scores when it was given intravenously 5 min after ischemia, and in mice, administration of a metalloporphyrin catalytic antioxidant had marked neuroprotective effects against focal ischemic insults.

TL;DR: It is demonstrated that a subset of mice with partial deficiency of the mitochondrial superoxide dismutase show increased incidence of spontaneous and handling-induced seizures that correlates with chronic mitochondrial oxidative stress, and an age-related decrease in the expression of glial glutamate transporters is shown, suggesting that oxidant-induced inhibition of glutamate transport may play a mechanistic role in rendering some Sod2(-/+) mice susceptible to seizures.

TL;DR: The data suggest that the KD initially produces mild oxidative and electrophilic stress, which may systemically activate the Nrf2 pathway via redox signaling, leading to chronic cellular adaptation, induction of protective proteins, and improvement of the mitochondrial redox state.