M
Massimo Rizzi
Researcher at Mario Negri Institute for Pharmacological Research
Publications - 40
Citations - 2420
Massimo Rizzi is an academic researcher from Mario Negri Institute for Pharmacological Research. The author has contributed to research in topics: Epilepsy & Epileptogenesis. The author has an hindex of 24, co-authored 38 publications receiving 2296 citations.
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Journal ArticleDOI
Glia activation and cytokine increase in rat hippocampus by kainic acid-induced status epilepticus during postnatal development.
Massimo Rizzi,Carlo Perego,Marisa Aliprandi,Cristina Richichi,Teresa Ravizza,Daniele Colella,Jana Velískǒvá,Solomon L. Moshé,M. Grazia De Simoni,Annamaria Vezzani +9 more
TL;DR: The data show that the pattern of glia activation and cytokine gene transcription induced by SE is age-dependent and neuronal injury in the hippocampus occurs only when cytokines are induced and their synthesis precedes the appearance of neuronal damage.
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Limbic seizures induce P-glycoprotein in rodent brain: Functional implications for pharmacoresistance
Massimo Rizzi,Silvio Caccia,Giovanna Guiso,Cristina Richichi,Jan A. Gorter,Eleonora Aronica,Marisa Aliprandi,Renzo Bagnati,Roberto Fanelli,Maurizio D'Incalci,Rosario Samanin,Annamaria Vezzani +11 more
TL;DR: Changes in P-gp mRNA levels occur in limbic areas after both acute and chronic epileptic activity, suggesting that seizure-induced mdr mRNA expression contributes to MDR in epilepsy.
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Targeting oxidative stress improves disease outcomes in a rat model of acquired epilepsy
Alberto Pauletti,Gaetano Terrone,Tawfeeq Shekh-Ahmad,Alessia Salamone,Teresa Ravizza,Massimo Rizzi,Anna Pastore,Rosaria Pascente,Li-Ping Liang,Bianca R. Villa,Silvia Balosso,Andrey Y. Abramov,Erwin A. van Vliet,Ennio Del Giudice,Eleonora Aronica,Daniel J. Antoine,Manisha Patel,Matthew C. Walker,Annamaria Vezzani +18 more
TL;DR: Targeting oxidative stress with clinically used drugs for a limited time window starting early after injury significantly improves long-term disease outcomes and may be considered for patients exposed to potential epileptogenic insults.
Journal ArticleDOI
Inflammatory response and glia activation in developing rat hippocampus after status epilepticus.
Teresa Ravizza,Massimo Rizzi,Carlo Perego,Cristina Richichi,Jana Velíšková,Solomon L. Moshé,M. Grazia De Simoni,Annamaria Vezzani +7 more
TL;DR: The activation of microglia and astrocytes, induction of cytokines, and hippocampal neuronal damage, 4 and 24 h after kainic acid–induced status epilepticus in postnatal day 9, 15, and 21 rats is investigated.
Journal ArticleDOI
Neuropeptide Y gene therapy decreases chronic spontaneous seizures in a rat model of temporal lobe epilepsy
Francesco Noé,Allan-Hermann Pool,Jari Nissinen,Marco Gobbi,Ross J. Bland,Massimo Rizzi,Claudia Balducci,Francesco Ferraguti,Gunther Sperk,Matthew J. During,Asla Pitkänen,Annamaria Vezzani +11 more
TL;DR: The data show that this gene therapy strategy decreases spontaneous seizures and suppresses their progression in chronic epileptic rats, thus representing a promising new therapeutic strategy.