Li Tu

TL;DR: ASA-MTX-GdⅢ NPs could be catalyzed by tumor-specific overexpressed endogenous FeⅡ ions to generate sufficient ROS for enhancing the main chemodynamic efficacy, which could exert a synergistic effect with the assistant chemotherapy of MTX.

TL;DR: Self-recognizing and stimulus-responsive carrier-free metal-coordinated nanotheranostics that showed strongly synergistic potency for tumor photo-chemotherapy under the precise guidance of magnetic resonance/photoacoustic/fluorescence imaging, thereby achieving highly effective tumor curing efficiency.

TL;DR: An electrochemical sensor based on core-shell nanostructured copper sulfide@Prussian blue composites (CuS@PB) was investigated for ascorbic acid (AA) detection, demonstrating a great prospect for quantitative detection to AA of various fields.

TL;DR: Using in vitro transforming growth factor (TGF)-β-induced EndMT model, it is demonstrated that the cardiovascular protective effect of MoS2 QDs against EndMT acted through triggering T FEB nucleus translocation and restoring an impairment of autophagic flux, whereas genetic suppression of TFEB impaired the protective action of Mo S2 QD against End MT.

TL;DR: It is shown that exposure of microglia to MoS2 QDs triggered NLRP3 inflammasome activation as revealed by the cleavage of the inactive precursor of caspase-1 to its active form and the increased release of downstream pro-inflammatory cytokines, resulting inmicroglia cell death that occurred through casp enzyme-1-dependent pyroptosis.