Liang Qu

TL;DR: This work presents an approach, called leveraging endogenous ADAR for programmable editing of RNA (LEAPER), that employs short engineered ADAR-recruiting RNAs (arRNAs) to recruit native ADAR1 or ADAR2 enzymes to change a specific adenosine to inosine.

TL;DR: In this paper , a circular RNA (circRNA) vaccine that elicited potent neutralizing antibodies and T cell responses by expressing the trimeric RBD of the spike protein, providing robust protection against SARS-CoV-2 in both mice and rhesus macaques.

TL;DR: LEAPER 2.0 provides a new design of arRNA that enables more precise, efficient RNA editing with broad applicability for therapy and basic research, and Engineered circ-arRNAs enhanced the efficiency and fidelity of editing endogenous CTNNB1 and mutant TP53 transcripts in cell culture.

TL;DR: In this article, a circular RNA (circRNA) vaccine that encodes the trimeric RBD of SARS-CoV-2 spike protein was reported, which could be rapidly produced via in vitro transcription and is highly stable without nucleotide modification.

TL;DR: An amendment to this paper has been published and can be accessed via a link at the top of the paper.