Zhuo Zhou

TL;DR: This study shows that Sars-CoV-2 perturbs host innate immune response via both its structural and nonstructural proteins, and thus provides insights into the pathogenesis of SARS-Cov-2.

TL;DR: This work presents an approach, called leveraging endogenous ADAR for programmable editing of RNA (LEAPER), that employs short engineered ADAR-recruiting RNAs (arRNAs) to recruit native ADAR1 or ADAR2 enzymes to change a specific adenosine to inosine.

TL;DR: Wang et al. as discussed by the authors reported that SARS-CoV-2 nsp12, the viral RNA-dependent RNA polymerase (RdRp), suppresses host antiviral responses.

TL;DR: It is reported that SARSCoV-2 infection activates the innate immune response through the cytosolic DNA sensing cGASSTING pathway, and it is shown that host cells’ self-nucleic acids can be employed as a “danger signal” to alarm the immune system.

TL;DR: In this paper, the authors performed a genome-wide barcoded-CRISPRa screen to identify novel host factors that enable SARS-CoV-2 infection, including LDLRAD3, TMEM30A, and CLEC4G.