L
Lianglin Zhang
Researcher at University of Texas MD Anderson Cancer Center
Publications - 6
Citations - 637
Lianglin Zhang is an academic researcher from University of Texas MD Anderson Cancer Center. The author has contributed to research in topics: Vascular endothelial growth factor & Vascular endothelial growth factor A. The author has an hindex of 6, co-authored 6 publications receiving 629 citations.
Papers
More filters
Journal Article
Wild-type p53 suppresses angiogenesis in human leiomyosarcoma and synovial sarcoma by transcriptional suppression of vascular endothelial growth factor expression.
TL;DR: In this paper, the effect of restoring wild-type p53 function on angiogenesis in human soft-tissue sarcoma harboring mutant p53 was evaluated using an in vivo Matrigel plug assay.
Journal ArticleDOI
Combined trastuzumab and paclitaxel treatment better inhibits ErbB-2-mediated angiogenesis in breast carcinoma through a more effective inhibition of Akt than either treatment alone
S B S Kristine Klos,Xiaoyan Zhou,Sangkyou Lee,Lianglin Zhang,Wentao Yang,Yoichi Nagata,Dihua Yu,Dihua Yu +7 more
TL;DR: The authors investigated whether ErbBB‐2‐mediated angiogenic responses would be inhibited more effectively by the combined treatment of paclitaxel plus trastuzumab.
Journal Article
Combined Anti-Fetal Liver Kinase 1 Monoclonal Antibody and Continuous Low-Dose Doxorubicin Inhibits Angiogenesis and Growth of Human Soft Tissue Sarcoma Xenografts by Induction of Endothelial Cell Apoptosis
Lianglin Zhang,Dihua Yu,Daniel J. Hicklin,Jonathan A. F. Hannay,Lee M. Ellis,Raphael E. Pollock +5 more
TL;DR: Combined DC101 and continuous low-dose doxorubicin resulted in more effective growth inhibition of SKLMS-1 and RD xenografts than has been observed with any agent alone in a long-term s.c. tumor Xenograft model.
Journal Article
Up-Regulation of Vascular Endothelial Growth Factor in Breast Cancer Cells by the Heregulin-β1-activated p38 Signaling Pathway Enhances Endothelial Cell Migration
Shunbin Xiong,Rebecca Grijalva,Lianglin Zhang,Nina T. Nguyen,Peter W.T. Pisters,Raphael E. Pollock,Dihua Yu +6 more
TL;DR: Results show that HRG can activate p38 MAPK to enhance V EGF transcription via an upstream HRG response element, leading to increased VEGF secretion and angiogenic response in breast cancer cells.
Journal ArticleDOI
Vascular Endothelial Growth Factor Overexpression by Soft Tissue Sarcoma Cells: Implications for Tumor Growth, Metastasis, and Chemoresistance
Lianglin Zhang,Jonathan A. F. Hannay,Juehui Liu,Parimal Das,Maocheng Zhan,Theresa Nguyen,Daniel J. Hicklin,Dihua Yu,Raphael E. Pollock,Dina Lev +9 more
TL;DR: It is concluded that VEGF is a critical determinant of STS growth and metastasis and that STS chemoresistance, in this model, is a process induced by the interplay between STS cells and tumor-associated endothelial cells.