J
Juehui Liu
Researcher at University of Texas MD Anderson Cancer Center
Publications - 12
Citations - 742
Juehui Liu is an academic researcher from University of Texas MD Anderson Cancer Center. The author has contributed to research in topics: Phosphorylation & Wild type. The author has an hindex of 11, co-authored 12 publications receiving 688 citations. Previous affiliations of Juehui Liu include University of Texas Health Science Center at Houston.
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Journal ArticleDOI
Rad51 overexpression contributes to chemoresistance in human soft tissue sarcoma cells: a role for p53/activator protein 2 transcriptional regulation
Jonathan A. F. Hannay,Juehui Liu,Quan Sheng Zhu,Svetlana Bolshakov,Lan Li,Peter W.T. Pisters,Alexander J. Lazar,Dihua Yu,Raphael E. Pollock,Dina Lev +9 more
TL;DR: The studies reported here show that Rad51 protein is overexpressed in a large panel of human STS specimens, and these findings point to a potential novel strategy for molecular-based treatments that may be of relevance to patients burdened by STS.
Journal ArticleDOI
MiR-155 Is a Liposarcoma Oncogene That Targets Casein Kinase-1α and Enhances β-Catenin Signaling
Pingyu Zhang,Kate Lynn J. Bill,Kate Lynn J. Bill,Kate Lynn J. Bill,Juehui Liu,Eric D. Young,Tingsheng Peng,Svetlana Bolshakov,Aviad Hoffman,Yechun Song,Elizabeth G. Demicco,Dolores Lopez Terrada,Chad J. Creighton,Matthew L. Anderson,Alexander J. Lazar,George G. Calin,Raphael E. Pollock,Dina Lev,Dina Lev,Dina Lev +19 more
TL;DR: The results point to important functions for miR-155 and β-catenin signaling in progression of liposarcoma, revealing mechanistic vulnerabilities that might be exploited for both prognostic and therapeutic purposes.
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Activated MET Is a Molecular Prognosticator and Potential Therapeutic Target for Malignant Peripheral Nerve Sheath Tumors
Keila E. Torres,Quansheng Zhu,Kate Lynn J. Bill,Kate Lynn J. Bill,Gonzalo Lopez,Gonzalo Lopez,Markus P. Ghadimi,Xianbiao Xie,Eric D. Young,Juehui Liu,Theresa Nguyen,Svetlana Bolshakov,Roman Belousov,Suizhau Wang,Guy Lahat,Jun Liu,Belinda F Hernandez,Alexander J. Lazar,Dina Lev,Dina Lev +19 more
TL;DR: An important role is shown for MET in MPNST, supporting continued investigation of novel anti-MET therapies in this clinical context and Informative prognosticators and novel therapies are crucially needed to improve MPN ST management and outcomes.
Journal ArticleDOI
Combining PCI-24781, a novel histone deacetylase inhibitor, with chemotherapy for the treatment of soft tissue sarcoma.
Gonzalo Lopez,Juehui Liu,Wenhong Ren,Wei Wei,Suizhao Wang,Guy Lahat,Quan Sheng Zhu,William G. Bornmann,David J. McConkey,Raphael E. Pollock,Dina Lev +10 more
TL;DR: Although single-agent PCI-24781 had modest effects on STS growth and metastasis, marked inhibition was observed when combined with chemotherapy, and this novel molecular-based combination may be applicable to multiple STS histologic subtypes, and potentially merits rigorous evaluation in human STS clinical trials.
Journal ArticleDOI
Autophagic survival in resistance to histone deacetylase inhibitors: novel strategies to treat malignant peripheral nerve sheath tumors.
Gonzalo Lopez,Keila E. Torres,Juehui Liu,Belinda F Hernandez,Eric D. Young,Roman Belousov,Svetlana Bolshakov,Alexander J. Lazar,John M. Slopis,Ian E. McCutcheon,David J. McConkey,Dina Lev,Dina Lev +12 more
TL;DR: Findings that strongly rationalize clinical evaluation of HDACi in malignant peripheral nerve sheath tumors (MPNST), a class of highly aggressive, therapeutically resistant, and commonly fatal malignancies that occur sporadically or in patients with the inherited neurofibromatosis type-1 (NF1) syndrome, are reported.