L
Lianqi Zhang
Researcher at Tsinghua University
Publications - 4
Citations - 1576
Lianqi Zhang is an academic researcher from Tsinghua University. The author has contributed to research in topics: Coronavirus & Transcription (biology). The author has an hindex of 4, co-authored 4 publications receiving 1068 citations.
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Journal ArticleDOI
Structure of the RNA-dependent RNA polymerase from COVID-19 virus.
Yan Gao,Yan Gao,Liming Yan,Yucen Huang,Fengjiang Liu,Yao Zhao,Lin Cao,Tao Wang,Qianqian Sun,Zhenhua Ming,Lianqi Zhang,Ji Ge,Litao Zheng,Ying Zhang,Haofeng Wang,Haofeng Wang,Yan Zhu,Chen Zhu,Tianyu Hu,Tian Hua,Bing Zhang,Xiuna Yang,Jun Li,Haitao Yang,Zhi-Jie Liu,Wenqing Xu,Luke W. Guddat,Quan Wang,Zhiyong Lou,Zihe Rao +29 more
TL;DR: The structure of the COVID-19 virus polymerase essential for viral replication provides a basis for the design of new antiviral drugs that target viral RdRp, also named nsp12, and it appears to be a primary target for the antiviral drug remdesivir.
Journal ArticleDOI
Delicate structural coordination of the Severe Acute Respiratory Syndrome coronavirus Nsp13 upon ATP hydrolysis.
Zhihui Jia,Liming Yan,Zhilin Ren,Lijie Wu,Jin Wang,Jing Guo,Litao Zheng,Zhenhua Ming,Lianqi Zhang,Zhiyong Lou,Zihe Rao,Zihe Rao,Zihe Rao +12 more
TL;DR: The structure of the full-length Nsp13 helicase of SARS-CoV (SARS-Nsp13) is presented and the structural coordination of its five domains is investigated, which provides new insights into the Replication and Transcription Complex (RTC) of CoVs.
Journal ArticleDOI
Structural and Biochemical Characterization of Endoribonuclease Nsp15 Encoded by Middle East Respiratory Syndrome Coronavirus.
TL;DR: Evidence is provided on how the activity of Nsp15 may be functionally mediated by catalytic residues, oligomeric assembly, RNA binding efficiency, or the possible association with other nonstructural proteins.
Posted ContentDOI
Structure of RNA-dependent RNA polymerase from 2019-nCoV, a major antiviral drug target
Yan Gao,Yan Gao,Liming Yan,Yucen Huang,Fengjiang Liu,Yao Zhao,Lin Cao,Tao Wang,Qianqian Sun,Zhenhua Ming,Lianqi Zhang,Ji Ge,Litao Zheng,Ying Zhang,Haofeng Wang,Haofeng Wang,Yan Zhu,Chen Zhu,Tianyu Hu,Tian Hua,Bing Zhang,Xiuna Yang,Jun Li,Haitao Yang,Zhi-Jie Liu,Wenqing Xu,Luke W. Guddat,Quan Wang,Zhiyong Lou,Zihe Rao +29 more
TL;DR: The RNA-dependent RNA polymerase (RdRp), also named nsp12, is a key component of coronaviral replication/transcription machinery and appears to be a primary target for the antiviral drug remdesivir as mentioned in this paper.