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Wenqing Xu
Researcher at ShanghaiTech University
Publications - 21
Citations - 5265
Wenqing Xu is an academic researcher from ShanghaiTech University. The author has contributed to research in topics: Indole test & Catalysis. The author has an hindex of 11, co-authored 21 publications receiving 3285 citations. Previous affiliations of Wenqing Xu include Chinese Academy of Sciences & University of Colorado Boulder.
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Journal ArticleDOI
Structure of Mpro from SARS-CoV-2 and discovery of its inhibitors
Zhenming Jin,Zhenming Jin,Xiaoyu Du,Yechun Xu,Yong-Qiang Deng,Meiqin Liu,Yao Zhao,Bing Zhang,Xiaofeng Li,Leike Zhang,Chao Peng,Yinkai Duan,Jing Yu,Lin Wang,Kailin Yang,Fengjiang Liu,Ren-Di Jiang,Xing-Lou Yang,Tian You,Liu X,Xiuna Yang,Fang Bai,Hong Liu,Xiang Liu,Luke W. Guddat,Wenqing Xu,Wenqing Xu,Gengfu Xiao,Cheng-Feng Qin,Zhengli Shi,Hualiang Jiang,Hualiang Jiang,Zihe Rao,Zihe Rao,Zihe Rao,Haitao Yang +35 more
TL;DR: A programme of structure-assisted drug design and high-throughput screening identifies six compounds that inhibit the main protease of SARS-CoV-2, demonstrating the ability of this strategy to isolate drug leads with clinical potential.
Journal ArticleDOI
Structure of the RNA-dependent RNA polymerase from COVID-19 virus.
Yan Gao,Yan Gao,Liming Yan,Yucen Huang,Fengjiang Liu,Yao Zhao,Lin Cao,Tao Wang,Qianqian Sun,Zhenhua Ming,Lianqi Zhang,Ji Ge,Litao Zheng,Ying Zhang,Haofeng Wang,Haofeng Wang,Yan Zhu,Chen Zhu,Tianyu Hu,Tian Hua,Bing Zhang,Xiuna Yang,Jun Li,Haitao Yang,Zhi-Jie Liu,Wenqing Xu,Luke W. Guddat,Quan Wang,Zhiyong Lou,Zihe Rao +29 more
TL;DR: The structure of the COVID-19 virus polymerase essential for viral replication provides a basis for the design of new antiviral drugs that target viral RdRp, also named nsp12, and it appears to be a primary target for the antiviral drug remdesivir.
Journal ArticleDOI
Structural Basis for RNA Replication by the SARS-CoV-2 Polymerase.
Quan Wang,Jiqin Wu,Haofeng Wang,Haofeng Wang,Yan Gao,Qiaojie Liu,An Mu,An Mu,Wenxin Ji,Wenxin Ji,Liming Yan,Yan Zhu,Chen Zhu,Xiang Fang,Xiaobao Yang,Yucen Huang,H. Gao,H. Gao,Fengjiang Liu,Ji Ge,Qianqian Sun,Xiuna Yang,Wenqing Xu,Zhi-Jie Liu,Haitao Yang,Zhiyong Lou,Biao Jiang,Luke W. Guddat,Peng Gong,Zihe Rao,Zihe Rao,Zihe Rao +31 more
TL;DR: The molecular basis of SARS-CoV-2 RNA replication is examined by determining the cryo-EM structures of the stalled pre-/post- translocated polymerase complexes and the inhibition mechanisms of the triphosphate metabolite of remdesivir are investigated through structural and kinetic analyses.
Journal ArticleDOI
Gold(I)-catalyzed tandem cyclization approach to tetracyclic indolines
TL;DR: Two highly stereoselective cationic gold(I)-catalyzed tandem cyclization reactions of alkynylindoles are described, demonstrating a novel and general strategy to rapidly construct highly functionalized polycyclic indolines.
Posted ContentDOI
Structure-based drug design, virtual screening and high-throughput screening rapidly identify antiviral leads targeting COVID-19
Zhenming Jin,Zhenming Jin,Xiaoyu Du,Yechun Xu,Yong-Qiang Deng,Meiqin Liu,Yao Zhao,Bing Zhang,Xiaofeng Li,Leike Zhang,Chao Peng,Yinkai Duan,Jing Yu,Lin Wang,Kailin Yang,Fengjiang Liu,Ren-Di Jiang,Xing-Lou Yang,Tian You,Liu X,Xiuna Yang,Fang Bai,Hong Liu,Xiang Liu,Luke W. Guddat,Wenqing Xu,Wenqing Xu,Gengfu Xiao,Cheng-Feng Qin,Zhengli Shi,Hualiang Jiang,Hualiang Jiang,Zihe Rao,Zihe Rao,Zihe Rao,Haitao Yang +35 more
TL;DR: The results demonstrate the efficacy of this screening strategy, and establishes a new paradigm for the rapid discovery of drug leads with clinical potential in response to new infectious diseases where no specific drugs or vaccines are available.