Y
Yan Zhu
Researcher at ShanghaiTech University
Publications - 8
Citations - 2374
Yan Zhu is an academic researcher from ShanghaiTech University. The author has contributed to research in topics: Viral replication & RNA polymerase. The author has an hindex of 7, co-authored 8 publications receiving 1541 citations.
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Journal ArticleDOI
Structure of the RNA-dependent RNA polymerase from COVID-19 virus.
Yan Gao,Yan Gao,Liming Yan,Yucen Huang,Fengjiang Liu,Yao Zhao,Lin Cao,Tao Wang,Qianqian Sun,Zhenhua Ming,Lianqi Zhang,Ji Ge,Litao Zheng,Ying Zhang,Haofeng Wang,Haofeng Wang,Yan Zhu,Chen Zhu,Tianyu Hu,Tian Hua,Bing Zhang,Xiuna Yang,Jun Li,Haitao Yang,Zhi-Jie Liu,Wenqing Xu,Luke W. Guddat,Quan Wang,Zhiyong Lou,Zihe Rao +29 more
TL;DR: The structure of the COVID-19 virus polymerase essential for viral replication provides a basis for the design of new antiviral drugs that target viral RdRp, also named nsp12, and it appears to be a primary target for the antiviral drug remdesivir.
Journal ArticleDOI
Structural Basis for RNA Replication by the SARS-CoV-2 Polymerase.
Quan Wang,Jiqin Wu,Haofeng Wang,Haofeng Wang,Yan Gao,Qiaojie Liu,An Mu,An Mu,Wenxin Ji,Wenxin Ji,Liming Yan,Yan Zhu,Chen Zhu,Xiang Fang,Xiaobao Yang,Yucen Huang,H. Gao,H. Gao,Fengjiang Liu,Ji Ge,Qianqian Sun,Xiuna Yang,Wenqing Xu,Zhi-Jie Liu,Haitao Yang,Zhiyong Lou,Biao Jiang,Luke W. Guddat,Peng Gong,Zihe Rao,Zihe Rao,Zihe Rao +31 more
TL;DR: The molecular basis of SARS-CoV-2 RNA replication is examined by determining the cryo-EM structures of the stalled pre-/post- translocated polymerase complexes and the inhibition mechanisms of the triphosphate metabolite of remdesivir are investigated through structural and kinetic analyses.
Journal ArticleDOI
Structural basis for the inhibition of SARS-CoV-2 main protease by antineoplastic drug carmofur.
Zhenming Jin,Zhenming Jin,Yao Zhao,Yuan Sun,Bing Zhang,Haofeng Wang,Haofeng Wang,Yan Wu,Yan Zhu,Chen Zhu,Tianyu Hu,Xiaoyu Du,Xiaoyu Du,Yinkai Duan,Jing Yu,Xiaobao Yang,Xiuna Yang,Kailin Yang,Xiang Liu,Luke W. Guddat,Gengfu Xiao,Leike Zhang,Haitao Yang,Zihe Rao,Zihe Rao,Zihe Rao +25 more
TL;DR: The X-ray crystal structure of SARS-CoV-2 with inhibitor carmofur reveals the mechanism of action of this compound and opens the way to develop more potent drugs.
Journal ArticleDOI
Crystal structure of SARS-CoV-2 main protease in complex with protease inhibitor PF-07321332.
Journal ArticleDOI
Structures of cell wall arabinosyltransferases with the anti-tuberculosis drug ethambutol.
Lu Zhang,Lu Zhang,Yao Zhao,Yao Zhao,Yan Gao,Lijie Wu,Ruogu Gao,Ruogu Gao,Qi Zhang,Yinan Wang,Yinan Wang,Chengyao Wu,Fangyu Wu,Sudagar S. Gurcha,Natacha Veerapen,Sarah M. Batt,Wei Zhao,Ling Qin,Xiuna Yang,Manfu Wang,Yan Zhu,Bing Zhang,Lijun Bi,Xian’en Zhang,Haitao Yang,Luke W. Guddat,Wenqing Xu,Quan Wang,Quan Wang,Jun Li,Gurdyal S. Besra,Zihe Rao +31 more
TL;DR: Cryo–electron microscopy and x-ray crystal structures of mycobacterial EmbA-EmbB and EmbC-EmbC complexes in the presence of their glycosyl donor and acceptor substrates and with ethambutol provide a structural basis for understanding the biochemical function and inhibition of arabinosyltransferases and the development of new anti-tuberculosis agents.