L
Liem Nguyen
Researcher at Case Western Reserve University
Publications - 38
Citations - 2977
Liem Nguyen is an academic researcher from Case Western Reserve University. The author has contributed to research in topics: Mycobacterium tuberculosis & Tuberculosis. The author has an hindex of 23, co-authored 38 publications receiving 2694 citations. Previous affiliations of Liem Nguyen include University of Basel & University Hospitals of Cleveland.
Papers
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Journal ArticleDOI
Protein Kinase G from Pathogenic Mycobacteria Promotes Survival Within Macrophages
Anne Walburger,Anil Koul,Giorgio Ferrari,Liem Nguyen,Cristina Prescianotto-Baschong,Kris Huygen,Bert Klebl,Charles J. Thompson,Gerald Bacher,Jean Pieters +9 more
TL;DR: It is found that the eukaryotic-like serine/threonine protein kinase G from pathogenic mycobacteria was secreted within macrophage phagosomes, inhibiting phagosome-lysosome fusion and mediating intracellular survival of myc Cobacteria.
Journal ArticleDOI
Ancestral antibiotic resistance in Mycobacterium tuberculosis.
Rowan P. Morris,Liem Nguyen,John Gatfield,Kevin C. Visconti,Kien T. Nguyen,Dirk Schnappinger,Sabine Ehrt,Yang Liu,Leonid Heifets,Jean Pieters,Gary K. Schoolnik,Charles J. Thompson +11 more
TL;DR: A complementary system that coordinates resistance to drugs that have penetrated the envelope, allowing mycobacteria to tolerate diverse classes of antibiotics that inhibit cytoplasmic targets is described, allowing M. tuberculosis or multidrug-resistant derivatives more antibiotic-sensitive.
Journal ArticleDOI
The Trojan horse: survival tactics of pathogenic mycobacteria in macrophages
Liem Nguyen,Jean Pieters +1 more
TL;DR: Recent progress in understanding the molecular biology of host-mycobacteria interactions is providing insights into these survival tactics of M. tuberculosis.
Journal ArticleDOI
Interaction of pathogenic mycobacteria with the host immune system
TL;DR: The definition of key molecules that are important for intracellular survival opens the possibility to develop new drugs to combat mycobacterial diseases.
Book ChapterDOI
Molecular Biology of Drug Resistance in Mycobacterium tuberculosis
TL;DR: The current understanding of molecular mechanisms underlying the profound drug resistance of M. tuberculosis is reviewed, which is essential for the development of more effective antibiotics, which are not only potent against drug resistant M tuberculosis strains but also help shorten the current treatment courses required for drug susceptible TB.