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Bert Klebl
Researcher at GPC Biotech
Publications - 76
Citations - 4564
Bert Klebl is an academic researcher from GPC Biotech. The author has contributed to research in topics: Chemistry & Medicine. The author has an hindex of 27, co-authored 60 publications receiving 3883 citations. Previous affiliations of Bert Klebl include Semmelweis University.
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Journal ArticleDOI
Frequent and Focal FGFR1 Amplification Associates with Therapeutically Tractable FGFR1 Dependency in Squamous Cell Lung Cancer
Jonathan Weiss,Martin L. Sos,Danila Seidel,Martin Peifer,Thomas Zander,Johannes M. Heuckmann,Roland T. Ullrich,Roopika Menon,Sebastian Maier,Alex Soltermann,Holger Moch,Patrick Wagener,Florian Fischer,Stefanie Heynck,Mirjam Koker,Jakob Schöttle,Frauke Leenders,Franziska Gabler,Ines Dabow,Silvia Querings,Lukas C. Heukamp,Hyatt Balke-Want,Sascha Ansén,Daniel Rauh,Ingelore Baessmann,Janine Altmüller,Zoe Wainer,Matthew Conron,Gavin M. Wright,Prudence A. Russell,Ben Solomon,Elisabeth Brambilla,Christian Brambilla,Philippe Lorimier,Steinar Sollberg,Odd Terje Brustugun,Walburga Engel-Riedel,Corinna Ludwig,Iver Petersen,Jörg Sänger,Joachim H. Clement,Harry J.M. Groen,Wim Timens,Hannie Sietsma,Erik Thunnissen,Egbert F. Smit,Daniëlle A.M. Heideman,Federico Cappuzzo,C. Ligorio,Stefania Damiani,Michael Hallek,Rameen Beroukhim,William Pao,Bert Klebl,Matthias Baumann,Reinhard Buettner,Karen Ernestus,Erich Stoelben,Jürgen Wolf,Peter Nürnberg,Peter Nürnberg,Sven Perner,Roman K. Thomas +62 more
TL;DR: F focal FGFR1 amplification is common in squamous cell lung cancer and associated with tumor growth and survival, suggesting that FGFR inhibitors may be a viable therapeutic option in this cohort of patients.
Journal ArticleDOI
Protein Kinase G from Pathogenic Mycobacteria Promotes Survival Within Macrophages
Anne Walburger,Anil Koul,Giorgio Ferrari,Liem Nguyen,Cristina Prescianotto-Baschong,Kris Huygen,Bert Klebl,Charles J. Thompson,Gerald Bacher,Jean Pieters +9 more
TL;DR: It is found that the eukaryotic-like serine/threonine protein kinase G from pathogenic mycobacteria was secreted within macrophage phagosomes, inhibiting phagosome-lysosome fusion and mediating intracellular survival of myc Cobacteria.
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Gasdermin D plays a vital role in the generation of neutrophil extracellular traps
Gabriel Sollberger,Axel Choidas,Garth L. Burn,Peter Habenberger,Raffaella Di Lucrezia,Susanne Kordes,Sascha Menninger,Jan Eickhoff,Peter Nussbaumer,Bert Klebl,Renate Krüger,Alf Herzig,Arturo Zychlinsky +12 more
TL;DR: It is demonstrated that G SDMD is activated in neutrophils, during the generation of neutrophil extracellular traps (NETs), and proposed that GSDMD also plays an essential function in NETosis.
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The E3 ligase Cbl-b and TAM receptors regulate cancer metastasis via natural killer cells
Magdalena Paolino,Axel Choidas,Stephanie Wallner,Blanka Pranjic,Iris Uribesalgo,Stefanie Loeser,Amanda M. Jamieson,Wallace Y. Langdon,Fumiyo Ikeda,Juan Pablo Fededa,Shane J. F. Cronin,Roberto Nitsch,Carsten Schultz-Fademrecht,Jan Eickhoff,Sascha Menninger,Anke Unger,Robert Torka,Thomas Gruber,Reinhard Hinterleitner,Gottfried Baier,Dominik Wolf,Axel Ullrich,Bert Klebl,Josef M. Penninger +23 more
TL;DR: This novel TAM/Cbl-b inhibitory pathway shows that it might be possible to develop a ‘pill’ that awakens the innate immune system to kill cancer metastases, and the anticoagulant warfarin exerts anti-metastatic activity in mice via Cbl- b/TAM receptors in NK cells.
Journal ArticleDOI
Interplay between mycobacteria and host signalling pathways.
TL;DR: This review highlights the strategies employed by mycobacteria to subvert host-cell signalling and identifies key molecules involved in these processes that might serve as potential targets for new antimycobacterial therapies.