https://digital.library.adelaide.edu.au/dspace/bitstream/2440/98611/2/hdl_98611.pdf

Designing a broad-spectrum integrative approach for cancer prevention and treatment

Isoxazoline containing natural products as anticancer agents: a review.

Stilbene is an abundant structural scaffold in nature, and stilbene-based compounds have been widely reported for their biological activity. Notably, (E)-resveratrol and its natural stilbene-containing derivatives have been extensively investigated as cardioprotective, potent antioxidant, anti-inflammatory, and anticancer agents. Starting from its potent chemotherapeutic activity against a wide variety of cancers, the stilbene scaffold has been subject to synthetic manipulations with the aim of obtaining new analogues with improved anticancer activity and better bioavailability. Within the last decade, the majority of new synthetic stilbene derivatives have demonstrated significant anticancer activity against a large number of cancer cell lines, depending on the type and position of substituents on the stilbene skeleton. This review focuses on the structure-activity relationship of the key compounds containing a stilbene scaffold and describes how the structural modifications affect their anticancer activity.

Anticancer Activity of Stilbene-Based Derivatives.

폐양액 활용을 위한 Filamentous Cyanobacteria의 선발 및 최적배양

Current status and contemporary approaches to the discovery of antitumor agents from higher plants.

Recent progress is described in an ongoing collaborative multidisciplinary research project directed towards the purification, structural characterization, chemical modification, and biological evaluation of new potential natural product anticancer agents obtained from a diverse group of organisms, comprising tropical plants, aquatic and terrestrial cyanobacteria, and filamentous fungi Information is provided on how these organisms are collected and processed The types of bioassays are indicated in which initial extracts, chromatographic fractions, and purified isolated compounds of these acquisitions are tested Several promising biologically active lead compounds from each major organism class investigated are described, and these may be seen to be representative of a very wide chemical diversity

/pdf/discovery-of-anticancer-agents-of-diverse-natural-origin-3ngmolb95w.pdf

Lihui Xu

Papers

Discovery of Anticancer Agents of Diverse Natural Origin.