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Esperanza J. Carcache de Blanco
Researcher at Ohio State University
Publications - 68
Citations - 1528
Esperanza J. Carcache de Blanco is an academic researcher from Ohio State University. The author has contributed to research in topics: Apoptosis & Cancer. The author has an hindex of 21, co-authored 62 publications receiving 1225 citations.
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Journal ArticleDOI
Discovery of Anticancer Agents of Diverse Natural Origin.
A. Douglas Kinghorn,Esperanza J. Carcache de Blanco,David M. Lucas,H. Liva Rakotondraibe,Jimmy Orjala,Djaja D. Soejarto,Djaja D. Soejarto,Nicholas H. Oberlies,Cedric J. Pearce,Mansukh C. Wani,Brent R. Stockwell,Joanna E. Burdette,Steven M. Swanson,James R. Fuchs,Mitchell Phelps,Lihui Xu,Xiaoli Zhang,Yongchun Shen +17 more
TL;DR: Several promising biologically active lead compounds from each major organism class investigated are described, and these may be seen to be representative of a very wide chemical diversity.
Journal ArticleDOI
Discovery of anticancer agents of diverse natural origin
A. Douglas Kinghorn,Esperanza J. Carcache de Blanco,Hee Byung Chai,Jimmy Orjala,Norman R. Farnsworth,Djaja D. Soejarto,Nicholas H. Oberlies,Mansukh C. Wani,David J. Kroll,Cedric J. Pearce,Steven M. Swanson,Robert Kramer,William C. Rose,Craig R. Fairchild,Gregory D. Vite,Stuart Emanuel,David Jarjoura,Frederick Cope +17 more
TL;DR: A collaborative multidisciplinary research project is described in which new natural product anticancer drug leads are obtained from a diverse group of organisms, constituted by tropical plants, aquatic cyanobacteria, and filamentous fungi.
Journal ArticleDOI
Cytotoxic xanthone constituents of the stem bark of Garcinia mangostana (mangosteen).
Ah-Reum Han,J. A. Kim,Daniel D. Lantvit,Leonardus B.S. Kardono,Soedarsono Riswan,Heebyung Chai,Esperanza J. Carcache de Blanco,Norman R. Farnsworth,Steven M. Swanson,A. Douglas Kinghorn +9 more
TL;DR: Bioassay-guided fractionation of a chloroform-soluble extract of Garcinia mangostana stem bark, using the HT-29 human colon cancer cell line and an enzyme-based ELISA NF-kappaB assay, led to the isolation of a new xanthone, 11-hydroxy-3-O-methyl-1-isomangostin (1).
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Green synthesis of hematite (α-Fe2O3) nanoparticles using Rhus punjabensis extract and their biomedical prospect in pathogenic diseases and cancer
Sania Naz,Mohammad Islam,Saira Tabassum,Nelson Freitas Fernandes,Esperanza J. Carcache de Blanco,Muhammad Zia +5 more
TL;DR: In this paper, the authors explored Rhus punjabensis extract potential as both reducing and capping agent for phytomediated synthesis of hematite nanoparticles from ferric chloride precursor.
Journal ArticleDOI
Resorcylic Acid Lactones with Cytotoxic and NF-κB Inhibitory Activities and Their Structure–Activity Relationships
Sloan Ayers,Tyler N. Graf,Audrey F. Adcock,David J. Kroll,Susan Matthew,Esperanza J. Carcache de Blanco,Qi Shen,Steven M. Swanson,Mansukh C. Wani,Cedric J. Pearce,Nicholas H. Oberlies +10 more
TL;DR: In the latter assay, compounds 1 and 5 displayed sub-micromolar activities that were on par with the positive control, and as such, these compounds may serve as a lead scaffold for future medicinal chemistry studies.