Liliya F. Saifina

TL;DR: The antiviral activity of the 1,2,3-triazolyl nucleoside analogues 4i and 8n against H1N1 (A/PR/8/34) influenza virus can be explained by their influence on the functioning of the polymerase acidic protein (PA) of RNA-dependent RNA polymerase (RdRP).

TL;DR: A series of 1,2,3-triazolyl nucleoside analogues was synthesized via the CuAAC reaction of N1-alkynyl uracil, 6-methyluracil and 3,6-dimethyl uracilic, thymine and quinazolin-2,4-dione with protected azido β-d -ribofuranose.

TL;DR: In this paper, the static electron density (ED) was obtained via multipole refinement against these data, and the presence of low-intense but nonrandom positive residual density peaks revealed that the structure was complicated by the minor conformational static disorder.

TL;DR: In this paper, triphenylphosphonium (TPP) conjugates of 1,2,3-triazolyl nucleoside analogues were synthesized by coupling with 8-bromoctyl- or 10- bromdecyltriphenylPHPOSonium bromide and evaluated for the in vitro antibacterial activity against S. aureus.

TL;DR: A series of 1,2,3-triazolyl nucleoside analogues in which polymethylene linkers were attached to both nitrogen atoms of the heterocycle moiety or to the C-5 and N-3 atoms of 6-methyluracil moiety was synthesized as discussed by the authors.