Showing papers in "Tetrahedron Letters in 2019"

TL;DR: In this article, the σ-donor properties of NHC ligands were measured using a simple 1H NMR measurement of ligand precursors to determine the selectivity and reactivity in transition-metal-catalysis.

TL;DR: Nondissociative chain walking is a mechanism where an alkylmetal species undergoes rapid β-hydride elimination and reinsertion to move the metal center along the alkyls chain without dissociating an alkene intermediate during the migration process.

TL;DR: The scope, applications, and understanding of photoinduced, copper-catalysis have advanced considerably in recent times as mentioned in this paper, and many of these transformations exploit the distinctive properties of photoactive copper species to establish original synthetic methodology and reveal novel reactivity.

TL;DR: In this article, a simple I 2 O 5 -mediated method for the construction of sulfonylated benzofurans has been developed under metal-free conditions, which can be efficiently achieved through the oxidative cyclization of 1,6-enynes and arylsulfonylhydrazides.

TL;DR: In this article, small dipeptides were used as chiral organocatalysts under solvent-free and high-speed ball milling conditions, with focus on the asymmetric aldol addition reaction.

TL;DR: This review aims to summarize the current state of the field and what is known about the mechanisms of resistance so that the QACs of the future can be designed to be evermore efficacious and utilized to unearth the remaining mysteries that surround bacteria's resistance to them.

TL;DR: In this article, a simple and efficient method has been developed for construction of sulfonylated quinolines via coupling of haloquinolines and sulfonyl chlorides in water.

TL;DR: A visible-light promoted photoredox catalysed, green one-pot approach for the amidation of carboxylic acids with amines has been developed for the synthesis of diverse aliphatic and aromatic amides and may hold great potential for a comprehensive display of biologically interesting peptide synthesis and amino acid modification.

TL;DR: In this article, pyrene derivatives such as pyrenes having chiral side chains, chiral oligomers bearing multiple pyrene rings, and encapsulated by γ-cyclodextrins were observed to have CPL switching upon the complexation/decomplexation of metal ions.

TL;DR: In this paper, an environmentally benign α-sulfonated cyclic ketone derivatives were prepared by using shelf-stable arylsulfonyl hydrazides as aryl sulfonyl radical precursor and electrons as oxidizing reagents.

TL;DR: In this article, a review describes recent strategic advances for the activation of benzylic C-H bonds for the catalytic formation of C-C bonds, i.e., strategies that generate benzyric radicals or benzyl anions.

TL;DR: In this article, an efficient synthesis of functionalized iminoisoindolinone derivatives was achieved via a mild electrochemical oxidative C H/N H functionalization/intramolecular annulations with isocyanides in undivided cell equipped with a nickel cathode.

TL;DR: In this article, an undivided electrochemical cell equipped with glassy carbon electrodes employing LiClO4 as a supporting electrolyte was developed for 3-selenylated imidazopyridine derivatives.

TL;DR: In this paper, a visible light promoted, photoredox catalysed, green one-pot approach for the alkylation of amine substrates with sp2 carbon has been developed.

TL;DR: In this article, a highly regioselective synthesis of 2-substituted indoles was realized through Ir(III)-catalyzed C H functionalization of N-phenylpyridin-2-amines followed by the reaction with sulfoxonium ylides and intramolecular cyclization under mild conditions.

TL;DR: In this article, a series of 5-substituted 1H-tetrazoles have been efficiently synthesized in moderate to excellent yields (68-90%) under mild reaction conditions by combining aryl aldehydes, hydroxylamine hydrochloride with sodium azide.

TL;DR: In this article, a series of achiral and chiral diene and related ligands in transition-metal complexes is evaluated by percent buried volume (%Vbur) based on their molecular structures by X-ray analysis.

TL;DR: The potential of flow microreactor chemistry in chemical science and chemical production has been discussed in this paper, where a mini-review illustrates the potential of Flow microreactors for novel transformations via functional organolithiums that cannot be achieved using a conventional macro batch reactor.

TL;DR: A new analogue of gambierone, 44-methylgambierone was isolated from the benthic dinoflagellate Gambierdiscus australes collected from Raoul Island (Rangitahua/Kermadec Islands) as mentioned in this paper.

TL;DR: In this article, three simple non-planar D-π-A TPA-based isomers (TPA-o, tPA-m, and tpa-p) were designed and synthesized via Suzuki reaction with higher yields.

TL;DR: In this paper, a method for the synthesis of gem-difluoroally-lboronates via copper-catalyzed defluorinative borylation of α-trifluoromethyl alkenes with B2pin2 using Xantphos as ligand and NaOtBu as base was developed.

TL;DR: In this paper, a rhodium-catalyzed ortho-C H functionalization and annulation between enaminones and sulfoxonium ylides was developed, affording a series of multi-substituted naphthalenes in good to moderate yields with excellent functional group compatibility.

TL;DR: In this paper, a simple procedure to obtain 1,5-disubstituted 1,2,3-triazoles, using the Er(OTf)3/[mpy]OTf/H2O catalytic system is described.

TL;DR: In this paper, it was shown that diaryliodonium(III) triflates bearing a trimethoxybenzene (TMP) auxiliary are more reactive than the reported selective aryl-transfer iodonium salts in the N-arylation of benzimidazoles and other types of azole compounds under catalytic conditions.

TL;DR: In this paper, the authors combine the advantages of homogeneous and heterogeneous catalysis by immobilizing TEMPO into a water-soluble temperature responsive polymer, which showed excellent activity in the selective oxidation of alcohols below the LCST and can be easily recovered.

TL;DR: In this article, the ferric chloride-promoted direct trifluoromethylselenolation of indoles and other nitrogen-containing heterocyclic compounds in water was performed by employing TsSeCF3 reagent.

TL;DR: An efficient multicomponent synthesis of Ugi compounds comprising coumarin backbone has been achieved by employing one pot five component sequential Knoevenagel-Ugi reaction.

TL;DR: In this paper, a novel on-off-on fluorescence chemosensor BP based on benzothiazole for relay recognition of Fe3+ and PPi was designed and synthesized.

TL;DR: A mild and efficient one-pot visible light-induced method has been developed for the aerobic oxidation of saturated carbon conjugated with pyridine moiety with an important conversion in medicinal and synthetic organic chemistry as mentioned in this paper.

TL;DR: The first iron-catalyzed Ortoleva-King type protocol towards the synthesis of these fused heterocyclic compounds, employing cheap and easily available FeCl3·6H2O and molecular iodine as the catalytic system is described.