Showing papers in "The International Journal of Biochemistry & Cell Biology in 2019"

TL;DR: Exosomes from hypoxia-treated human ADSCs possess a higher capacity to enhance angiogenesis in fat grafting, at least partially, via regulating VEGF/VEGF-R signaling.

TL;DR: Results indicate that ADSC-derived exosomes ameliorate cardiac damage after MI by activating S1P/SK1/S1PR1 signaling and promoting macrophage M2 polarization.

TL;DR: The cancer stem cell origin and their involvement in angiogenesis, metastasis and therapy-resistance are discussed and different therapeutic approaches to eradicate the same are summarized for the successful treatment of breast cancer.

TL;DR: Research is needed to establish its long-term benefits if VR is to be adopted into mainstream protocols for analgesia management and a range of study designs with collection of patient self-report and clinical data together to develop bespoke interventions for different cohorts are needed.

TL;DR: Experimental results thus far obtained strongly suggest that the most important function of polyamines is at the level of translation.

TL;DR: An overview on the physicochemical properties of ZnPcs and biological results obtained both in vitro and in more complex models, such as 3D cell cultures, chicken chorioallantoic membranes and tumor-bearing mice are presented.

TL;DR: In this review, in addition to the regulation of CD133, and its involvement in cancer initiation, and development, the recent updates on how CD133 modulates cancer dissemination, and therapeutic resistance are provided.

TL;DR: This mini-review highlights the understanding of the modular regulatory principles of lncRNA interactions in CSCs and elaborate on how can lncRNAs impact CSC properties via interacting with other macromolecules at the epigenetic, transcriptional, and post-transcriptional levels.

TL;DR: By modulating the miR-155/Tim-3 pathway, repression of NEAT1 restrained CD8+T cell apoptosis and enhanced the cytolysis activity against HCC, implying an effective target for improving the outcome of immunotherapy.

TL;DR: The diversity, molecular structure, and principal electrophysiological properties of T-type channels are introduced and their role in neuronal development, and their pathophysiological role in the nervous system are highlighted.

TL;DR: The identity of cancer stem cells (CSCs) remains an enigma, with the question outstanding of whether CSCs are fixed entities or plastic cell states in response to microenvironmental cues as discussed by the authors.

TL;DR: This review provides a concise overview of autophagy and its importance in cellular and organismal homeostasis, with emphasis on aging, stem cells, neuronal cells, immunity, inflammation, and cancer.

TL;DR: The circRNA expression profile in ovarian cancer tissues is identified and the existence and expression of six randomly selected differentially expressed circRNAs are verified and it is found that circHIPK3 is an important regulator of ovarian cancer progression.

TL;DR: This study found the direct delivery of HEKa-MVs expressing miR-21 mimics significantly promoted the healing of skin wound in diabetic rats and provided for the first time the basis for the potential application of microvesicles, and MV mi-21 in particular for wound healing.

TL;DR: Analysis of RSPO function and underlying mechanism in these stem cells has provided new insight into the regulatory roles of WNT signaling in stem cell behavior.

TL;DR: The critical axis of XIST/miR-429/ZEB1 in PC cell migration, invasion and EMT is identified, which may aid in developing new therapeutic strategies for PC.

TL;DR: It is demonstrated for the first time that miR-137 was able to promote sensitivity of PC cells to chemotherapy via inhibition of autophagy mediated by ATG5 and may act as a potential therapeutic target for pancreatic cancer.

TL;DR: The results of this work help to explain, at the molecular level, how ATP2A3 gene is regulated in breast cancer cells, and the benefits of RSV intake observed in epidemiological data, studies with animals, and in vitro models.

TL;DR: Small airways fibrosis is a target for new drug development that inhibit growth factor receptors, new antioxidants and particularly those that are targeted to mitochondria and inhibitors of cellular senescence or senolytic therapies.

TL;DR: A review and critical analysis of current research conducted in the field of ovarian cancer stem cells and their potential role in drug resistance including several signalling pathways within these cells that affect the viability of targeted therapies are presented.

TL;DR: In this article, the effects of lncRNA H19 on cell proliferation, migration, invasion and apoptosis in cell lines were performed by MTT assay, colony formation assay, Transwell assay and flow cytometry in vitro, and tumor formation was detected by xenograft nude mice model in vivo.

TL;DR: Characterization studies of the fibrocyte continue as does emerging conflicting data concerning the relationship to or with the lung fibroblast, and interesting comparisons with other pathologies are emerging involving the influence of circulating mesenchymal precursor cells on tissue responses.

TL;DR: In vivo targeting imaging of folic acid (FA) gold nanoparticles (AuNPs) through cysteamine (Cys) linking for targeted of human nasopharyngeal head and neck cancer by computed tomography (CT) illustrated that a small tumor is enhanced by X-ray attenuation and becomes visible by the molecularly targeted AuNPs.

TL;DR: This work reviews recent studies that have illustrated novel aspects of ST2/IL-33 signaling mediating cardiac fibrosis, and some newer biomolecular targets for the prevention and treatment of maladaptive remodeling.

TL;DR: The current state of ovarian CSC characterization, their contribution to disease resistance, recurrence and shed light on clinical trials that may target the CSC population are discussed.

TL;DR: These properties explain the modifications and the remodeling seen in AT and SM undergoing adaptive changes and represent a starting point for precise therapeutic targeting of SPARC-related pathways is conditions such as obesity, sarcopenia and diabetes.

TL;DR: It is confirmed that NEAT1, whose stability maintained by SRSF1, implicates gliomagenesis by regulating cell cycle, and both S RSF1 andNEAT1 may serve as promising targets for antineoplastic therapies.

TL;DR: Alginate-encapsulated WJMSCs could be an efficient cell contact-free system for developing stem cell-based therapies for CSCs, suggesting its anti-tumorigenic activity.

TL;DR: In vivo experiments revealed that the DVDMS-SDT resulted in an effective inhibition of tumor growth and prolonged the survival time of tumor-bearing mice, suggesting that DVDMS -SDT is very effective in treating Hepatocellular carcinoma without side effects.

TL;DR: Some of therapeutic uses of cancer stem cells in breast cancer are indicated, targeting surface specific markers and activated signaling pathways in their microenvironment, using various miRNAs, enhancement of CSCs apoptosis, differentiation therapy, blocking epithelial to mesenchymal transition and using different natural compounds.