L
Lin Yi
Researcher at South China Agricultural University
Publications - 41
Citations - 582
Lin Yi is an academic researcher from South China Agricultural University. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 9, co-authored 27 publications receiving 314 citations.
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Journal ArticleDOI
Autophagy enhances the replication of classical swine fever virus in vitro.
Jingjing Pei,Mingqiu Zhao,Zuodong Ye,Hongchao Gou,Jiaying Wang,Lin Yi,Xiao-Ying Dong,Wenjun Liu,Yongwen Luo,Ming Liao,Jinding Chen +10 more
TL;DR: It is shown that CSFV infection significantly increases the number of autophagy-like vesicles in the cytoplasm of host cells at the ultrastructural level, and alteration of cellular autophage by autophagic regulators and shRNAs affects progeny virus production.
Journal ArticleDOI
Current State of Global African Swine Fever Vaccine Development under the Prevalence and Transmission of ASF in China.
Keke Wu,Jiameng Liu,Lianxiang Wang,Shuangqi Fan,Zhaoyao Li,Yuwan Li,Lin Yi,Hongxing Ding,Mingqiu Zhao,Jinding Chen +9 more
TL;DR: The epidemic situation of ASF in China as of July 2020 is recapitulated and the latest research outcomes showed that attempts on ASF gene-deleted vaccines and virus-vectored vaccines have proven to provide complete homologous protection with promising efficacy.
Journal ArticleDOI
Absence of autophagy promotes apoptosis by modulating the ROS-dependent RLR signaling pathway in classical swine fever virus-infected cells
Jingjing Pei,Deng Jieru,Zuodong Ye,Jiaying Wang,Hongchao Gou,Wenjun Liu,Mingqiu Zhao,Ming Liao,Lin Yi,Jinding Chen +9 more
TL;DR: Data indicate that CSFV-induced autophagy delays apoptosis by downregulating ROS-dependent RLR signaling and thus contributes to virus persistent infection in host cells.
Journal ArticleDOI
CSFV induced mitochondrial fission and mitophagy to inhibit apoptosis.
Hongchao Gou,Mingqiu Zhao,Hailuan Xu,Jin Yuan,Wencheng He,Mengjiao Zhu,Hongxing Ding,Lin Yi,Jinding Chen +8 more
TL;DR: The preservation of mitochondrial proteins, upregulated apoptotic signals and decline of viral replication resulting from the silencing of Drp1 and Parkin in CSFV-infected cells suggested thatCSFV induced mitochondrial fission and mitophagy to enhance cell survival and viral persistence.
Journal ArticleDOI
Genetic diversity and positive selection analysis of classical swine fever virus isolates in south China.
Hai-Yan Shen,Jingjing Pei,Jialin Bai,Mingqiu Zhao,Chun-Mei Ju,Lin Yi,Yanmei Kang,Xuetao Zhang,Li-Jun Chen,Yin-Guang Li,Jiaying Wang,Jinding Chen +11 more
TL;DR: The envelope protein gene, E2, has undergone positive selection in 14 CSFV strains and two positively selected sites have been identified in this study, which could help to predict possible changes in virulence, the development of vaccines and disease control.