L
Lina Chen
Researcher at Alberta Children's Hospital
Publications - 45
Citations - 3066
Lina Chen is an academic researcher from Alberta Children's Hospital. The author has contributed to research in topics: Voltage-dependent calcium channel & Calcium channel. The author has an hindex of 26, co-authored 44 publications receiving 2571 citations. Previous affiliations of Lina Chen include Allen Institute for Brain Science & University of Calgary.
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Journal ArticleDOI
Prion protein attenuates excitotoxicity by inhibiting NMDA receptors.
Houman Khosravani,Yunfeng Zhang,Shigeki Tsutsui,Shahid Hameed,Christophe Altier,Jawed Hamid,Lina Chen,Michelle L. Villemaire,Zenobia Ali,Frank R. Jirik,Gerald W. Zamponi +10 more
TL;DR: It is shown that PrP-null mouse neurons exhibit enhanced and drastically prolonged N-methyl-d-aspartate (NMDA)–evoked currents as a result of a functional upregulation of NMDA receptors (NMDARs) containing NR2D subunits.
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The Cavβ subunit prevents RFP2-mediated ubiquitination and proteasomal degradation of L-type channels
Christophe Altier,Agustin Garcia-Caballero,Brett A. Simms,Haitao You,Lina Chen,Jan Walcher,H. William Tedford,Tamara Hermosilla,Gerald W. Zamponi +8 more
TL;DR: The coexpression of Cavβ interfered with ubiquitination and targeting of the channel to the ERAD complex, thereby facilitating export from the endoplasmic reticulum and promoting expression on the cell surface and Thus, Cavββ regulates the ubiquitinations and stability of the calcium channel complex.
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Aβ neurotoxicity depends on interactions between copper ions, prion protein, and N-methyl-d-aspartate receptors
Haitao You,Shigeki Tsutsui,Shahid Hameed,Thomas J. Kannanayakal,Lina Chen,Peng Xia,Jordan D. T. Engbers,Stuart A. Lipton,Peter K. Stys,Gerald W. Zamponi +9 more
TL;DR: A unifying molecular mechanism whereby toxic species of Aβ1–42 might mediate neuronal and synaptic injury, at least in part, by disrupting the normal copper-mediated, PrPC-dependent inhibition of excessive activity of this highly calcium-permeable glutamate receptor is provided.
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The CACNA1F Gene Encodes an L-Type Calcium Channel with Unique Biophysical Properties and Tissue Distribution
John E. McRory,Jawed Hamid,Clinton J. Doering,Esperanza Garcia,Robin L. Parker,Kevin S. Hamming,Lina Chen,Michael E. Hildebrand,Aaron M. Beedle,Laura Feldcamp,Gerald W. Zamponi,Terrance P. Snutch +11 more
TL;DR: Immunohistochemical analyses show that Cav1.4 is widely distributed outside the retina, including in the immune system, thus suggesting a broader role in human physiology, and the channel is ideally suited for tonic calcium influx at typical photoreceptor resting potentials.
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The Deubiquitinating Enzyme USP5 Modulates Neuropathic and Inflammatory Pain by Enhancing Cav3.2 Channel Activity
Agustin Garcia-Caballero,Vinicius M. Gadotti,Patrick L. Stemkowski,Norbert Weiss,Ivana A. Souza,Victoria Hodgkinson,Chris Bladen,Lina Chen,Jawed Hamid,Anne Pizzoccaro,Mickael Deage,Amaury François,Emmanuel Bourinet,Gerald W. Zamponi +13 more
TL;DR: Experiments reveal a cell signaling pathway that regulates T-type channel activity and their role in nociceptive signaling and reveal the role of USP5 in both inflammatory and neuropathic mouse models of mechanical hypersensitivity.