L
Linda Söderberg
Researcher at Karolinska Institutet
Publications - 28
Citations - 942
Linda Söderberg is an academic researcher from Karolinska Institutet. The author has contributed to research in topics: Amyloid & Amyloid beta. The author has an hindex of 14, co-authored 26 publications receiving 627 citations.
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Journal ArticleDOI
Accumulation of amyloid-β by astrocytes result in enlarged endosomes and microvesicle-induced apoptosis of neurons
Sofia Söllvander,Elisabeth Nikitidou,Robin Brolin,Linda Söderberg,Dag Sehlin,Lars Lannfelt,Anna Erlandsson +6 more
TL;DR: The results suggest that astrocytes play a central role in the progression of Alzheimer’s disease, by accumulating and spreading toxic Aβ species.
Journal ArticleDOI
The murine version of BAN2401 (mAb158) selectively reduces amyloid-β protofibrils in brain and cerebrospinal fluid of tg-ArcSwe mice.
Stina Tucker,Christer Möller,Karin Tegerstedt,Anna Lord,Hanna Laudon,Johan Sjödahl,Linda Söderberg,Erika Spens,Charlotte Sahlin,Erik Rollman Waara,Andrew Satlin,Pär Gellerfors,Gunilla Osswald,Lars Lannfelt +13 more
TL;DR: It is demonstrated that the humanized antibody BAN2401 and its murine version mAb158 exhibit a strong binding preference for Aβ protofibrils over Aβ monomers, and further support is provided in favor of its position as an attractive new candidate for AD immunotherapy.
Journal ArticleDOI
Amyloid-β protofibril levels correlate with spatial learning in Arctic Alzheimer’s disease transgenic mice
Anna Lord,Hillevi Englund,Linda Söderberg,Stina M. Fangmark Tucker,Fredrik Clausen,Lars Hillered,Marcia N. Gordon,Dave Morgan,Lars Lannfelt,Frida Ekholm Pettersson,Lars N.G. Nilsson +10 more
TL;DR: It is concluded that Aβ protofibrils accumulate in an age‐dependent manner in tg‐ArcSwe mice, although to a far lesser extent than total Aβ.
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An amyloid-β protofibril-selective antibody prevents amyloid formation in a mouse model of Alzheimer's disease
Anna Lord,Astrid Gumucio,Hillevi Englund,Dag Sehlin,Valentina Screpanti Sundquist,Linda Söderberg,Christer Möller,Pär Gellerfors,Lars Lannfelt,Frida Ekholm Pettersson,Lars N.G. Nilsson +10 more
TL;DR: It is suggested that Abeta protofibrils can be selectively cleared with immunotherapy in an animal model that display highly insoluble Abeta deposits, similar to those of Alzheimer's disease brain.
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Specific uptake of an amyloid-β protofibril-binding antibody-tracer in AβPP transgenic mouse brain.
Kristina Magnusson,Dag Sehlin,Stina Syvänen,Marie M. Svedberg,Ola Philipson,Linda Söderberg,Karin Tegerstedt,Mats Holmquist,Pär Gellerfors,Vladimir Tolmachev,Gunnar Antoni,Gunnar Antoni,Lars Lannfelt,Håkan Hall,Lars N.G. Nilsson,Lars N.G. Nilsson +15 more
TL;DR: The in vitro and ex vivo characteristics of a new antibody-based radioactive ligand, [125I]mAb158, which binds to Aβ protofibrils with high affinity are described, which was specifically taken up in brain of transgenic mice expressing amyloid-β protein precursor (AβPP) as shown ex vivo.