G
Gunnar Antoni
Researcher at Uppsala University
Publications - 186
Citations - 9298
Gunnar Antoni is an academic researcher from Uppsala University. The author has contributed to research in topics: Medicine & In vivo. The author has an hindex of 37, co-authored 171 publications receiving 8288 citations. Previous affiliations of Gunnar Antoni include Uppsala University Hospital.
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Journal ArticleDOI
Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B.
William E. Klunk,Henry Engler,Agneta Nordberg,Yanming Wang,G. Blomqvist,Daniel P. Holt,Mats Bergström,Irina Savitcheva,Guo Feng Huang,Sergio Estrada,Birgitta Ausén,Manik L. Debnath,Julien Barletta,Julie C. Price,Johan Sandell,Brian J. Lopresti,Anders Wall,Pernilla Koivisto,Gunnar Antoni,Chester A. Mathis,Bengt Långström +20 more
TL;DR: The results suggest that PET imaging with the novel tracer, PIB, can provide quantitative information on amyloid deposits in living subjects.
Journal Article
Synthesis of L- and D-[methyl-11C]methionine.
Bengt Långström,Gunnar Antoni,Per Gullberg,Christer Halldin,P. Malmborg,Kjell Någren,Annika Rimland,Hans Svärd +7 more
TL;DR: This report describes the synthesis of L- and D-[methyl-11C]methionine in pure enantiomeric forms with an optical purity higher than 99% in 40%-90% radiochemical yields.
Journal ArticleDOI
In Vivo Visualization of Amyloid Deposits in the Heart with 11C-PIB and PET
Gunnar Antoni,Mark Lubberink,Mark Lubberink,Sergio Estrada,Jan Axelsson,Kristina Carlson,Lars Lindsjö,Tanja Kero,Tanja Kero,Bengt Långström,Sven-Olof Granstam,Sara Rosengren,Ola Vedin,Cecilia Wassberg,Cecilia Wassberg,Gerhard Wikström,Per Westermark,Jens Ahm Sørensen +17 more
TL;DR: 11C-PIB and PET could be a method to study systemic amyloidosis of type AL and ATTR affecting the heart and should be investigated further both as a diagnostic tool and as a noninvasive method for treatment follow-up.
Journal ArticleDOI
Human positron emission tomography studies of brain neurokinin 1 receptor occupancy by aprepitant.
Mats Bergström,Richard Hargreaves,H. Donald Burns,Michael R. Goldberg,David G. Sciberras,Scott A. Reines,Kevin J. Petty,Mattias Ögren,Gunnar Antoni,Bengt Långström,Olli Eskola,Mika Scheinin,Olof Solin,Anup K. Majumdar,M.L Constanzer,Wendy P Battisti,Thomas E. Bradstreet,Cynthia Gargano,Jarmo Hietala +18 more
TL;DR: Positron emission tomography imaging with [(18)F]SPA-RQ allows brain NK( 1) receptor occupancy by aprepitant to be predicted from plasma drug concentrations and can be used to guide dose selection for clinical trials of NK(1) receptor antagonists in central therapeutic indications.
Journal ArticleDOI
Simultaneous Intracerebral Microdialysis and Positron Emission Tomography in the Detection of Ischemia in Patients with Subarachnoid Hemorrhage
Per Enblad,Johann Valtysson,Jesper L. R. Andersson,Anders Lilja,Anders Lilja,Sven Valind,Sven Valind,Gunnar Antoni,Bengt Långström,Lars Hillered,Lennart Persson +10 more
TL;DR: In this article, the authors measured the regional CBF, the CMRO2, and oxygen extraction ratio (OER) with simultaneous positron emission tomography (PET) to directly correlate alterations in dialysate levels of energy-related metabolites (lactate, lactate/pyruvate ratio, hypoxanthine) and excitatory amino acids (EAAs) (glutamate and aspartate) to the energy state in the probe region as determined by PET.