Hanna Laudon

TL;DR: Glycosylation acceptor sequences were introduced into full-length human PS1, and the results showed that the first hydrophilic loop is oriented toward the lumen of the endoplasmic reticulum, whereas the N terminus and large hydrophobic loop are in the cytosol.

TL;DR: It is demonstrated that the humanized antibody BAN2401 and its murine version mAb158 exhibit a strong binding preference for Aβ protofibrils over Aβ monomers, and further support is provided in favor of its position as an attractive new candidate for AD immunotherapy.

TL;DR: It is postulate that variant plaques observed in this family are due in part to the effects of PS-1Δexon8 and that interaction between PS- 1 and various protein complexes are necessary for neuritic plaque formation.

TL;DR: It is demonstrated that coexpression of PS1 NTF and CTF functionally mimics expression of the full‐length PS1 protein and restores γ‐secretase activity in PS‐deficient mammalian cells.

TL;DR: The effects of modifications on the C terminus of PS1 on PS1 endoproteolysis, γ-secretase complex assembly, and activity in cells devoid of endogenous PS are investigated and suggest that the PS1 N- and C-terminal fragment intermolecular interactions are independent of an association with nicastrin and Aph-1.