L
Lindvi Gudmundsdotter
Researcher at Karolinska Institutet
Publications - 29
Citations - 732
Lindvi Gudmundsdotter is an academic researcher from Karolinska Institutet. The author has contributed to research in topics: Vaccination & Immune system. The author has an hindex of 15, co-authored 27 publications receiving 695 citations. Previous affiliations of Lindvi Gudmundsdotter include Swedish Institute.
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Journal ArticleDOI
Skin electroporation: effects on transgene expression, DNA persistence and local tissue environment.
Anna-Karin Roos,Fredrik Eriksson,James A. Timmons,Josefine Gerhardt,Ulrika Nyman,Lindvi Gudmundsdotter,Andreas Bråve,Britta Wahren,Pavel Pisa +8 more
TL;DR: This study investigates intradermal DNA electrovaccination in detail and describes the effects on expression of the vaccine antigen, plasmid persistence and the local tissue environment, finding that the combination of DNA and electroporation induced a significant up-regulation of pro-inflammatory genes.
Journal ArticleDOI
Recombinant Modified Vaccinia Ankara (MVA) effectively boosts DNA-primed HIV-specific immune responses in humans despite pre-existing vaccinia immunity.
Lindvi Gudmundsdotter,Charlotta Nilsson,Andreas Bråve,Bo Hejdeman,Patricia L. Earl,Bernard Moss,Merlin L. Robb,Josephine H. Cox,Nelson L. Michael,Mary A. Marovich,Gunnel Biberfeld,Eric Sandström,Britta Wahren +12 more
TL;DR: It is suggested that vaccinia-based vectors can be used to efficiently induce immune responses to vectored HIV-1 antigens, even in individuals with pre-existing immunity to vaccinia virus.
Journal ArticleDOI
Inhibiting HER3-Mediated Tumor Cell Growth with Affibody Molecules Engineered to Low Picomolar Affinity by Position-Directed Error-Prone PCR-Like Diversification
Magdalena Malm,Nina Kronqvist,Hanna Lindberg,Lindvi Gudmundsdotter,Tarek Bass,Fredrik Y. Frejd,Ingmarie Höidén-Guthenberg,Zohreh Varasteh,Anna Orlova,Vladimir Tolmachev,Stefan Ståhl,John Löfblom +11 more
TL;DR: A novel strategy for affinity maturation of Affibody molecules that is based on alanine scanning followed by design of library diversification to mimic the result from an error-prone PCR reaction, but with full control over mutated positions and thus less biases is explored.
Journal ArticleDOI
Biodistribution, persistence and lack of integration of a multigene HIV vaccine delivered by needle-free intradermal injection and electroporation.
Andreas Bråve,Lindvi Gudmundsdotter,Lindvi Gudmundsdotter,Eric Sandström,B. Kristian Haller,David Hallengärd,David Hallengärd,Anna-Karin Maltais,Alan D. King,Richard Stout,Pontus Blomberg,Urban Höglund,Bo Hejdeman,G. Biberfeld,Britta Wahren,Britta Wahren +15 more
TL;DR: It is demonstrated that plasmids persist in the skin at the site of injection for at least four months after immunization, and no association between plasmid DNA and genomic DNA could be detected as analyzed by qPCR following field inversion gel electrophoresis separating heavy and light DNA fractions.
Journal ArticleDOI
Engineering of a bispecific affibody molecule towards HER2 and HER3 by addition of an albumin-binding domain allows for affinity purification and in vivo half-life extension
Magdalena Malm,Tarek Bass,Lindvi Gudmundsdotter,Martin Lord,Fredrik Y. Frejd,Stefan Ståhl,John Löfblom +6 more
TL;DR: An alternative format for bispecific molecules was designed and investigated, in which two Affibody molecules were linked by an albumin‐binding domain (ABD) and showed simultaneous binding to the three target proteins (HER2, HER3, and albumin) when investigated in biosensor assays.