L
Lingna Guo
Researcher at Southeast University
Publications - Â 8
Citations - Â 403
Lingna Guo is an academic researcher from Southeast University. The author has contributed to research in topics: Hair cell & Medicine. The author has an hindex of 5, co-authored 5 publications receiving 284 citations. Previous affiliations of Lingna Guo include Nantong University.
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Journal ArticleDOI
Autophagy protects auditory hair cells against neomycin-induced damage.
Zuhong He,Lingna Guo,Yilai Shu,Qiaojun Fang,Han Zhou,Yongze Liu,Dingding Liu,Ling Lu,Xiaoli Zhang,Xiaoqiong Ding,Dong Liu,Mingliang Tang,Weijia Kong,Suhua Sha,Huawei Li,Xia Gao,Renjie Chai +16 more
TL;DR: It is demonstrated that moderate ROS levels can promote autophagy to recycle damaged cellular constituents and maintain cellular homeostasis, while the induction of Autophagy can inhibit apoptosis and protect the HCs by suppressing ROS accumulation after aminoglycoside injury.
Journal ArticleDOI
Knockdown of Foxg1 in supporting cells increases the trans-differentiation of supporting cells into hair cells in the neonatal mouse cochlea
Shasha Zhang,Yuan Zhang,Ying Dong,Lingna Guo,Zhong Zhang,Buwei Shao,Jieyu Qi,Han Zhou,Weijie Zhu,Xiaoqian Yan,Guodong Hong,Liyan Zhang,Xiaoli Zhang,Mingliang Tang,Chunjie Zhao,Xia Gao,Renjie Chai +16 more
TL;DR: It is found that Foxg1 conditional knockdown (cKD) in Sox2+ SCs and Lgr5+ progenitors at postnatal day (P)1 both led to large numbers of extra HCs, especially extra inner HCs (IHCs) at P7, and these extra IHCs with normal hair bundles and synapses could survive at least to P30.
Journal ArticleDOI
The role of FOXG1 in the postnatal development and survival of mouse cochlear hair cells.
Zuhong He,Zuhong He,Qiaojun Fang,Qiaojun Fang,He Li,Buwei Shao,Buwei Shao,Yuan Zhang,Yuan Zhang,Yuhua Zhang,Yuhua Zhang,Xiao Han,Rongrong Guo,Rongrong Guo,Cheng Cheng,Cheng Cheng,Lingna Guo,Lingna Guo,Lusen Shi,Ao Li,Chenjie Yu,Weijia Kong,Chunjie Zhao,Xia Gao,Renjie Chai +24 more
TL;DR: Results indicate that knockout of Foxg1 induces an extra row of HCs via Notch signaling inhibition and induces subsequent apoptosis of these HCs by inhibiting the Wnt, IGF, and EGF signaling pathways.
Journal ArticleDOI
Frizzled-9+ Supporting Cells Are Progenitors for the Generation of Hair Cells in the Postnatal Mouse Cochlea.
Shasha Zhang,Dingding Liu,Ying Dong,Zhong Zhang,Yuan Zhang,Han Zhou,Lingna Guo,Jieyu Qi,Ruiying Qiang,Mingliang Tang,Xia Gao,Chunjie Zhao,Xiaoyun Chen,Xiaoyun Qian,Renjie Chai +14 more
TL;DR: Data suggest that the Fzd9+ cells have a similar capacity for proliferation, differentiation, and HC generation as Lgr5+ progenitors and that FZd9 can be used as a more restricted marker of HC progenitor cells.
Journal ArticleDOI
Characterization of Lgr5+ Progenitor Cell Transcriptomes after Neomycin Injury in the Neonatal Mouse Cochlea
Shasha Zhang,Shasha Zhang,Yuan Zhang,Pengfei Yu,Yao Hu,Han Zhou,Lingna Guo,Xiaochen Xu,Xiaocheng Zhu,Muhammad Waqas,Muhammad Waqas,Jieyu Qi,Xiaoli Zhang,Yan Liu,Fangyi Chen,Mingliang Tang,Xiaoyun Qian,Haibo Shi,Xia Gao,Renjie Chai,Renjie Chai +20 more
TL;DR: This study has identified the genes that might regulate the proliferation and HC regeneration of Lgr5+ progenitors after neomycin injury, and investigations into the roles and mechanisms of these genes in the cochlea should be performed in the future to identify potential therapeutic targets for HC regeneration.