Zuhong He

TL;DR: It is demonstrated that moderate ROS levels can promote autophagy to recycle damaged cellular constituents and maintain cellular homeostasis, while the induction of Autophagy can inhibit apoptosis and protect the HCs by suppressing ROS accumulation after aminoglycoside injury.

TL;DR: FoxG1 affects the sensitivity of mimetic aging hair cells to inflammation by regulating autophagy pathways, and this study finds that cell death and apoptosis were significantly increased after LPS injury.

TL;DR: Graphene is able to accelerate NSC maturation during development, especially with regard to bioelectric evolvement, which provides a fundamental understanding of the role of conductive materials in tuning the membrane bioelectric properties in a graphene model and pave the way for future studies on the development of methods and materials for manipulating membrane property in a controllable way for NSC-based therapies.

TL;DR: Results indicate that knockout of Foxg1 induces an extra row of HCs via Notch signaling inhibition and induces subsequent apoptosis of these HCs by inhibiting the Wnt, IGF, and EGF signaling pathways.

TL;DR: The findings show that MA2 has a protective effect and improves the viability of HEI-OC1 cells after cisplatin treatment, and they provide new insights into potential therapeutic targets for the amelioration of cis platin-induced ototoxicity.