L
Linliu Peng
Researcher at Central South University
Publications - 21
Citations - 101
Linliu Peng is an academic researcher from Central South University. The author has contributed to research in topics: Spinocerebellar ataxia & Medicine. The author has an hindex of 3, co-authored 12 publications receiving 28 citations.
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Journal ArticleDOI
Biallelic Intronic AAGGG Expansion of RFC1 is Related to Multiple System Atrophy.
Linlin Wan,Zhao Chen,Na Wan,Mingjie Liu,Jin Xue,Hongsheng Chen,Youming Zhang,Yun Peng,Zhichao Tang,Yiqing Gong,Hongyu Yuan,Shang Wang,Qi Deng,Xuan Hou,Chunrong Wang,Huirong Peng,Yuting Shi,Linliu Peng,Lijing Lei,Ranhui Duan,Kun Xia,Rong Qiu,Lu Shen,Beisha Tang,Tetsuo Ashizawa,Hong Jiang +25 more
TL;DR: This study aimed to examine whether the pentanucleotide repeat (PNR) was related to multiple system atrophy (MSA), which shares a spectrum of symptoms with CANVAS.
Journal ArticleDOI
CRISPR/Cas9 mediated gene correction ameliorates abnormal phenotypes in spinocerebellar ataxia type 3 patient-derived induced pluripotent stem cells.
Lang He,Shang Wang,Linliu Peng,Huifang Zhao,Shuai Li,Xiaobo Han,Jean de Dieu Habimana,Zhao Chen,Chunrong Wang,Yun Peng,Huirong Peng,Yue Xie,Lijing Lei,Qi Deng,Linlin Wan,Na Wan,Hongyu Yuan,Yiqing Gong,Guangdong Zou,Zhiyuan Li,Tang Beisha,Hong Jiang +21 more
TL;DR: Wang et al. as mentioned in this paper showed that SCA3-iPSCs can be corrected by replacing the abnormal CAG expansions with normal repeats (17 CAG) using CRISPR/Cas9 mediated homologous recombination (HR) strategy.
Journal ArticleDOI
Prediction of the Age at Onset of Spinocerebellar Ataxia Type 3 with Machine Learning
Linliu Peng,Zhao Chen,Tiankai Chen,Lijing Lei,Zhe Long,Mingjie Liu,Qi Deng,Hongyu Yuan,Guangdong Zou,Linlin Wan,Chunrong Wang,Huirong Peng,Yuting Shi,Puzhi Wang,Yun Peng,Shang Wang,Lang He,Yue Xie,Zhichao Tang,Na Wan,Yiqing Gong,Xuan Hou,Lu Shen,Kun Xia,Jinchen Li,Chao Chen,Zuping Zhang,Rong Qiu,Beisha Tang,Hong Jiang +29 more
TL;DR: In polyglutamine (polyQ) disease, the investigation of the prediction of a patient's age at onset (AAO) facilitates the development of disease‐modifying intervention and underpins the delay of disease onset and progression.
Journal ArticleDOI
New Model for Estimation of the Age at Onset in Spinocerebellar Ataxia Type 3.
Linliu Peng,Zhao Chen,Zhe Long,Mingjie Liu,Lijing Lei,Chunrong Wang,Huirong Peng,Yuting Shi,Yun Peng,Qi Deng,Shang Wang,Guangdong Zou,Linlin Wan,Hongyu Yuan,Lang He,Yue Xie,Zhichao Tang,Na Wan,Yiqing Gong,Xuan Hou,Lu Shen,Kun Xia,Jinchen Li,Chao Chen,Rong Qiu,Thomas Klockgether,Thomas Klockgether,Beisha Tang,Hong Jiang +28 more
TL;DR: Wang et al. as mentioned in this paper developed an appropriate parametric survival model to predict patient's age at onset (AAO) for Spinocerebellar ataxia type 3/Machado-Joseph disease (SCA3/MJD) populations from mainland China.
Journal ArticleDOI
Generation of an induced pluripotent stem cell line (XHCSUi001-A) from urine cells of a patient with spinocerebellar ataxia type 3.
Lang He,Wei Ye,Zhao Chen,Chunrong Wang,Huifang Zhao,Shuai Li,Linliu Peng,Xiaobo Han,Tiancheng Zhou,Li Zhiyuan,Beisha Tang,Hong Jiang +11 more
TL;DR: The induced pluripotent stem cell line XHCSUi001-A generated from urine cells of a female spinocerebellar ataxia type 3/Machado-Joseph disease patient is generated by using the integration-free methods and retained the disease-causing ATXN3 mutation.