Zhao Chen

TL;DR: A term NIID-related disorders (NIIDRD), which will include NIID and other related neurodegenerative diseases caused by the expanded GGC repeat within human-specific NOTCH2NLC, is suggested.

TL;DR: A genotype-channelopathy-phenotype correlation network underlying PE etiology is proposed which could provide guidance for future therapeutics and may help in the development of new drugs for PE.

TL;DR: Two independent preclinical trials with valproic acid (VPA), a promising therapeutic HDAC inhibitor, found that VPA could both increase the acetylation levels of hist one H3 and histone H4 and reduce the early apoptotic rate of cells without inhibiting the aggregation of mutant ataxin-3 proteins in MJDtr-Q68- expressing cells.

TL;DR: This study provides the first global miRNA expression profile of ASD in China and suggests that the differentially expressed miR-34b may potentially explain the higher percentage of male ASD patients, and the aberrantly expressedmiR-103a-3p may contribute to the abnormal ubiquitin-mediated proteolysis observed in ASD.

TL;DR: It is found that miR‐25 reduced both wild‐type and polyQ‐expanded mutant ataxin‐3 protein levels by interacting with the 3′UTR of ATXN3 mRNA, and increased cell viability, decreased early apoptosis, and downregulated the accumulation of mutant atXn3 protein aggregates in SCA3/MJD cells.