L
Liping Tian
Researcher at Cleveland Clinic
Publications - 1
Citations - 594
Liping Tian is an academic researcher from Cleveland Clinic. The author has contributed to research in topics: Chemokine & Receptor. The author has an hindex of 1, co-authored 1 publications receiving 563 citations.
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SIGIRR, a negative regulator of Toll-like receptor-interleukin 1 receptor signaling.
David N Wald,Jinzhong Qin,Zhendong Zhao,Youcun Qian,Mayumi Naramura,Liping Tian,Jennifer E. Towne,John E. Sims,George Stark Stark,Xiaoxia Li +9 more
TL;DR: Inflammation is enhanced in SIGIRR-deficient mice, as shown by their enhanced chemokine induction after IL-1 injection and reduced threshold for lethal endotoxin challenge and biochemical analysis indicated that SIGirR binds to the TLR–IL-1R signaling components in a ligand-dependent way.