J
Jinzhong Qin
Researcher at Cleveland Clinic
Publications - 14
Citations - 5224
Jinzhong Qin is an academic researcher from Cleveland Clinic. The author has contributed to research in topics: Receptor & Signal transduction. The author has an hindex of 10, co-authored 10 publications receiving 4802 citations. Previous affiliations of Jinzhong Qin include Cleveland State University.
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Journal ArticleDOI
IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines
Jochen Schmitz,Alexander Owyang,Elizabeth R. Oldham,Yaoli Song,Erin Murphy,Terril K. McClanahan,Gerard Zurawski,Mehrdad M. Moshrefi,Jinzhong Qin,Xiaoxia Li,Daniel M. Gorman,J. Fernando Bazan,Robert A. Kastelein +12 more
TL;DR: A member of theIL-1 family, IL-33, which mediates its biological effects via IL-1 receptor ST 2, activates NF-kappaB and MAP kinases, and drives production of T(H)2-associated cytokines from in vitro polarized T( H)2 cells is reported.
Journal ArticleDOI
SIGIRR, a negative regulator of Toll-like receptor-interleukin 1 receptor signaling.
David N Wald,Jinzhong Qin,Zhendong Zhao,Youcun Qian,Mayumi Naramura,Liping Tian,Jennifer E. Towne,John E. Sims,George Stark Stark,Xiaoxia Li +9 more
TL;DR: Inflammation is enhanced in SIGIRR-deficient mice, as shown by their enhanced chemokine induction after IL-1 injection and reduced threshold for lethal endotoxin challenge and biochemical analysis indicated that SIGirR binds to the TLR–IL-1R signaling components in a ligand-dependent way.
Journal ArticleDOI
The Toll–Interleukin-1 Receptor Member SIGIRR Regulates Colonic Epithelial Homeostasis, Inflammation, and Tumorigenesis
Hui Xiao,Muhammet F. Gulen,Muhammet F. Gulen,Jinzhong Qin,Jinzhong Qin,Jianhong Yao,Katarzyna Bulek,Danielle D. Kish,Cengiz Z. Altuntas,David N Wald,Caixia Ma,Hang Zhou,Vincent K. Tuohy,Robert L. Fairchild,Carol A. de la Motte,Daniel J. Cua,Bruce A. Vallance,Xiaoxia Li +17 more
TL;DR: Gut epithelium-derived SIGIRR is critical in controlling the homeostasis and innate immune responses of the colon to enteric microflora and reduced AOM+DSS-induced tumorigenesis.
Journal ArticleDOI
SIGIRR inhibits interleukin-1 receptor- and toll-like receptor 4-mediated signaling through different mechanisms.
TL;DR: Results indicate that SIGIRR inhibits IL-1 and LPS signaling pathways through differential mechanisms.
Journal ArticleDOI
Pellino 1 is required for interleukin-1 (IL-1)-mediated signaling through its interaction with the IL-1 receptor-associated kinase 4 (IRAK4)-IRAK-tumor necrosis factor receptor-associated factor 6 (TRAF6) complex.
TL;DR: A mammalian counterpart of Pellino is reported, termed Pellino 1, which is required for NFκB activation and IL-8 gene expression in response to IL-1, probably through its signal-dependent interaction with IRAK4, IRAK, and the tumor necrosis factor receptor-associated factor 6 (TRAF6).