L
Lisa E. Freed
Researcher at Massachusetts Institute of Technology
Publications - 117
Citations - 19035
Lisa E. Freed is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Tissue engineering & Cartilage. The author has an hindex of 63, co-authored 114 publications receiving 18408 citations. Previous affiliations of Lisa E. Freed include Charles Stark Draper Laboratory & Harvard University.
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Journal ArticleDOI
Biodegradable Polymer Scaffolds for Tissue Engineering
Lisa E. Freed,Gordana Vunjak-Novakovic,Robert J. Biron,Dana Burton Eagles,Daniel C. Lesnoy,Sandra K. Barlow,Robert Langer +6 more
TL;DR: The scaffold induced chondrocyte differentiation with respect to morphology and phenotype and represents a model cell culture substrate that may be useful for a variety of tissue engineering applications.
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Neocartilage formation in vitro and in vivo using cells cultured on synthetic biodegradable polymers.
TL;DR: These studies demonstrate the feasibility of culturing isolated chondrocytes on biodegradable polymer scaffolds to regenerate 3-D neocartilage.
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Functional assembly of engineered myocardium by electrical stimulation of cardiac myocytes cultured on scaffolds.
Milica Radisic,Hyoungshin Park,Helen Shing,Thomas Consi,Frederick J. Schoen,Robert Langer,Lisa E. Freed,Gordana Vunjak-Novakovic +7 more
TL;DR: It is hypothesized that excitation–contraction coupling, critical for the development of a normal heart, determines the development and function of engineered myocardium.
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Accordion-like honeycombs for tissue engineering of cardiac anisotropy.
George C. Engelmayr,Mingyu Cheng,Christopher J. Bettinger,Jeffrey T. Borenstein,Robert Langer,Lisa E. Freed +5 more
TL;DR: Accordion-like honeycombs can overcome principal structural-mechanical limitations of previous scaffolds, promoting the formation of grafts with aligned heart cells and mechanical properties more closely resembling native myocardium.
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Bioreactor cultivation conditions modulate the composition and mechanical properties of tissue-engineered cartilage.
Gordana Vunjak-Novakovic,Ivan Martin,Bojana Obradovic,Steven Treppo,Alan J. Grodzinsky,Robert Langer,Lisa E. Freed +6 more
TL;DR: It is suggested that the hydrodynamic conditions in tissue‐culture bioreactors can modulate the composition, morphology, mechanical properties, and electromechanical function of engineered cartilage.