Lisa Gawriyski

TL;DR: The Multiple Approaches Combined (MAC)-tag workflow is developed, which allows for both AP–MS and BioID analysis with a single construct and with almost identical protein purification and mass spectrometry (MS) identification procedures.

TL;DR: In this paper, the authors applied both affinity purification mass spectrometry (AP-MS) and the complementary proximity-based labeling method (BioID-MS), to map the interactions relevant to viral processing.

TL;DR: In this article , double homeobox 4 (DUX4) is expressed at the early pre-implantation stage in human embryos and it is shown that induced human DUX4 expression substantially alters the chromatin accessibility of non-coding DNA and activates thousands of newly identified transcribed enhancer-like regions, preferentially located within ERVL-MaLR repeat elements.

TL;DR: In this paper, the authors performed a molecular level system pathology analysis of the vitreous from 127 patients with Rhegmatogenous Retinal detachment using state-of-the art quantitative mass spectrometry to identify the individual key proteins, as well as the biochemical pathways contributing to the development of the disease.

TL;DR: In this paper, the authors present a comprehensive analysis of the interactomes of N6-methyladenosine (m6A) and N6,2'-O-dimethylADenosine(m6Am) enzymes, pointing to specific molecular mechanisms of their regulation.